@article{10.1371/journal.pone.0327958,

title = {Drug-loaded nanoparticles for intra-articular injection},

author = {Piaopiao Pan and Konstantina Simou and Yanting Ouyang and Lawrence Shere and Jon A. Preece and Simon W. Jones and Edward T. Davis and Yanling Lan and Zhenqiu Chen and Zhenyu Jason Zhang and Qingguo Li},

url = {https://doi.org/10.1371/journal.pone.0327958},

doi = {10.1371/journal.pone.0327958},

year  = {2026},

date = {2026-01-16},

urldate = {2026-01-16},

journal = {PLOS ONE},

volume = {21},

number = {1},

pages = {1-15},

publisher = {Public Library of Science},

abstract = {Drug loaded nanoparticles (NPs) were developed as a model intra-articular injection (IAI) formulation to mitigate early stage osteoarthritis (OA). Different types of celecoxib-loaded nanoparticles were prepared by a hybrid method that combines homogenization and solvent evaporation. The hydrodynamic diameter of the nanoparticles prepared were approximately 200 nm (PLLA: 238 ± 19 nm; PCL: 249 ± 28 nm; PLA: 252 ± 18 nm; PMMA: 234 ± 21), and zeta potential were about −40 mV (PLLA: −45.3 ± 2.3 mV; PCL: −38.0 ± 0.9 mV; PLA: −44.4 ± 3.2 mV; PMMA: −45.5 ± 2.7 mV). Our friction data evidences that nanoparticles could improve considerably the lubrication between a stainless steel sphere and a silicone elastomer that were used as model substrates. Quartz Crystal Microbalance (QCM) and Atomic Force Microscope (AFM) measurements were carried out to unravel the lubrication mechanism. The magnitude and amount of NPs adsorbed on the surface determines the effect of lubrication. Drug release experiment suggests that nanoparticles could release up to more than one week, when being compared with free celecoxib. NPs formulation exhibited excellent biocompatibility in cytotoxicity of chondrocytes experiment.},

keywords = {absorption, AFM, Atomic Force Microscopy, Elastometers, Friction, Lubrication, nanoparticles, openQCM, Osteoarthritis, Quartz Crystal Microbalance (QCM), Silicones, Skeletal joints},

pubstate = {published},

tppubtype = {article}

}

@article{piosik2022development,

title = {Development of Aminated Chitosan-Functionalized Magnetite Nanoparticles Enriched with Zinc Phthalocyanine: Detailed Photophysical and Model Cell Membrane Studies},

author = {Emilia Piosik and Michał Kotkowiak and Anna Modlińska and Dorota Chełminiak-Dudkiewicz and Marta Ziegler-Borowska},

url = {https://pubs.acs.org/doi/full/10.1021/acs.jpcc.2c04758},

doi = {https://doi.org/10.1021/acs.jpcc.2c04758},

year  = {2022},

date = {2022-01-01},

urldate = {2022-01-01},

journal = {The Journal of Physical Chemistry C},

publisher = {ACS Publications},

abstract = {Stimuli-induced anticancer therapies based on remotely activated nanoagents have drawn a great deal of attention as attractive alternatives to conventional therapies. The rapid development of nanomaterial functionalization in the past few decades has allowed for the tailoring of hybrid nanoagents with dual anticancer activity and the simultaneous application of two complementary stimuli-triggered therapies, enhancing a therapeutic effect. In this study, the synthesis and characterization of the novel aminated chitosan-coated magnetite nanoparticles (MNPs) with zinc(II) phthalocyanine (ZnPc) immobilized on their surface are presented. The synthetized ZnPc-MNPs combine the superparamagnetic properties of MNPs and the photosensitizing potential of ZnPc, which makes them promising nanomaterials with application potential in dual anticancer therapy based on hyperthermia and photodynamic effects. To understand and describe the mechanism of the ZnPc-MNPs action at the molecular level, we used a variety of surface approaches. Analytical techniques provided information on the structure, morphology, and size of the obtained ZnPc-MNPs. The stationary and time-resolved spectroscopy methods showed that the immobilization of the photosensitizer on the MNP surface boosts its photophysical parameters important from a photodynamic therapy point of view. Because of the decrease in the fraction of excitation energy exchange into heat of the ZnPc-MNPs, the singlet oxygen generation quantum yield increased to 0.57, improving its anticancer activity. Moreover, it was shown that ZnPc immobilized on the MNP surface does not aggregate even despite aggregation of the ZnPc-MNPs. As a result, ZnPc preserves its spectral properties beneficial for a photosensitizer. Finally, the effect of the ZnPc-MNPs on model cell membranes formed by applying a Langmuir technique was studied. The studies performed indicate that the MNPs introduced into the phospholipid monolayer at low concentrations do not significantly disturb its thermodynamic state, or the domain structure, which is promising in terms of their biocompatibility.},

keywords = {absorption, compression, lipids, monolayers, photosensitization},

pubstate = {published},

tppubtype = {article}

}

@article{avila2022effects,

title = {Effects of structural and chemical properties of surface coatings on the adsorption characteristics of proteins},

author = {Alejandro Avila-Sierra and Jose A Moreno and Kylee Goode and Taotao Zhu and Peter J Fryer and Alan Taylor and Zhenyu J Zhang},

url = {https://www.sciencedirect.com/science/article/pii/S0257897222009756},

doi = {https://doi.org/10.1016/j.surfcoat.2022.129054},

year  = {2022},

date = {2022-01-01},

urldate = {2022-01-01},

journal = {Surface and Coatings Technology},

pages = {129054},

publisher = {Elsevier},

abstract = {Using Quartz Crystal Microbalance with Dissipation (QCM-D) and Atomic Force Microscopy (AFM), a series of functional surface coatings were investigated to establish the effects of surface structural and chemical properties on the adsorption characteristics of two model proteins, β-Lactoglobulin (β-Lg) and Bovine Serum Albumin (BSA). We show that a free contact scenario, e.g., droplet, that is widely used to evaluate surface energy, is not always equivalent to biofouling conditions where the liquid phase is continuous - releasing the entrapped air from surface geometries could influence the interfacial adsorption process of biomolecules. We observed that surface structuration favoured adsorption of both proteins, especially for the protein of smaller size (β-Lg) as larger amounts of molecules would be required to fill surface geometries. Compact proteinaceous adlayers were observed on the coatings without structure, particularly those containing -CF3 ligands, suggesting stronger adhesion mechanisms due to conformational reorientations of both proteins to facilitate surface binding, especially BSA. In contrast, surface structure led to the formation of soft adlayers as the filling of surface cavities might affect protein conformation and favour protein superposition, hindering removal. We demonstrate how protein-surface binding affinity and packaging density of adsorbed proteins can be modulated as a synergistic effect of surface chemistry and structure, which is of especially importance to the development of anti-fouling coatings.},

key = {Protein adsorption, Functionalized coatings, Structured surfaces, QCM-D, AFM},

keywords = {absorption, AFM, Functionalized coatings, protein, Protein adsorption, QCM-D, Structured surfaces},

pubstate = {published},

tppubtype = {article}

}