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Scientific Paper

Revealing the role of epithelial mechanics and macrophage clearance during pulmonary epithelial injury recovery in the presence of carbon nanotubes

Journal article 2018

Dedy Septiadi, Wildan Abdussalam, Laura Rodriguez-Lorenzo, Miguel Spuch-Calvar, Joël Bourquin, Alke Petri-Fink, Barbara Rothen-Rutishauser

Advanced Materials, 30 (52), 1806181, 2018

View at publisher ↗

DOI 10.1002/adma.201806181

Summary

A wound-healing model for lung epithelium in which a small injury is created by photobleaching-induced apoptosis, leaving the dead cells in place. Epithelial cells push the apoptotic cells away while macrophages engulf them; carbon nanotubes disturb this repair by thickening actin, maturing focal adhesions and raising traction forces, which slows cell migration.

Summary written by the openQCM team. The original abstract is on the publisher’s page.

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