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Scientific Paper

Quartz crystal microbalance-based biosensing of proteins using molecularly imprinted polydopamine sensing films: Interplay between protein characteristics and molecular imprinting effect

Journal article 2023

Hui Jean Lim, Tridib Saha, Beng Ti Tey, Sunil Kumar Lal, Chien Wei Ooi

Surfaces and Interfaces, 39, 102904, 2023

View at publisher ↗ Full text ↗

DOI 10.1016/j.surfin.2023.102904

Summary

Molecularly imprinted polydopamine films on QCM crystals were studied as synthetic receptors for proteins, using pepsin, bovine and human serum albumin and lysozyme in liquid. Binding affinities in the micromolar range rival common bioreceptors; a pepsin-imprinted film favours its target (imprinting factor 5.78), and denser imprinted sites and the right sample pH emerge as the keys to selectivity.

Summary written by the openQCM team. The original abstract is on the publisher’s page.

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