Scientific Paper
In-line detection of monoclonal antibodies in the effluent of protein A chromatography with QCM sensor
Summary
A QCM sensor carrying protein A, placed in line after a protein A chromatography column, detects monoclonal antibodies leaking into the breakthrough fluid in real time and more sensitively than the usual UV signal. Because column and sensor share the same ligand, both can be regenerated in one step, which could help control loading in continuous multi-column capture.
Summary written by the openQCM team. The original abstract is on the publisher’s page.
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