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Scientific Paper

Rapid SARS-CoV-2 Detection Using High-Sensitivity Thickness Shear Mode Sensors

Cover image for Rapid SARS-CoV-2 Detection Using High-Sensitivity Thickness Shear Mode Sensors
Publication 2024

Sahera A. Saleh, Habib Alkalamouni, Karen Antar, Pierre Karam, Jit Muthuswamy, Hassan Zaraket, Massoud L. Khraiche

bioRxiv (Cold Spring Harbor Laboratory), 2024

View at publisher ↗

DOI 10.1101/2024.05.22.594713

Summary

A point-of-care test for COVID-19 in which a thickness shear mode (quartz) sensor with polyethylene glycol surface chemistry captures the SARS-CoV-2 nucleocapsid protein. With heat-inactivated virus it reached about 0.256 Hz per TCID50/mL and a detection limit near 150 TCID50/mL; the functionalised surface was checked by holographic microscopy, SEM-EDX and Raman.

Summary written by the openQCM team. The original abstract is on the publisher’s page.

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