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Scientific Paper

Quartz Crystal Microbalance-Based Biosensor for Rapid and Ultrasensitive SARS-CoV-2 Detection

Journal article 2025

Sahera Saleh, Habib Alkalamouni, Karen Antar, Joe Rahme, Michel Kazan, Pierre Karam, Jit Muthuswamy, Hassan Zaraket, Massoud L Khraiche

Journal of Pharmaceutical and Biomedical Analysis Open, 5, 100071, 2025

View at publisher ↗ Full text ↗

DOI 10.1016/j.jpbao.2025.100071

Summary

A QCM biosensor for the SARS-CoV-2 nucleocapsid protein, with a polyethylene glycol surface chemistry that improves sensitivity and specificity. It gives a result in about 15 minutes with a detection limit of 53.3 TCID50/mL and does not respond to influenza A; SEM, digital holographic microscopy and Raman spectroscopy confirm the surface is stable. The authors present it as a low-cost, open-source platform for settings with few resources.

Summary written by the openQCM team. The original abstract is on the publisher’s page.

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