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Influence of the SMN antibody on quartz crystal microbalance with dissipation (QCM-D) surface as an SMN protein biosensor

Cover image for Influence of the SMN antibody on quartz crystal microbalance with dissipation (QCM-D) surface as an SMN protein biosensor
Journal article 2023

Hanif Khoirudin, Rizky Aflaha, Eldiana Rully Arsetiyani, Ari Dwi Nugraheni, Dian Kesumapramudya Nurputra, Kuwat Triyana, Ahmad Kusumaatmaja

MRS Communications, 14 (1), 1–7, 2023

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DOI 10.1557/s43579-023-00492-6

Summary

A QCM-D biosensor for the survival motor neuron (SMN) protein, whose shortage causes spinal muscular atrophy. The crystal carries a polyvinyl alcohol nanofibre layer loaded with SMN antibodies, which stays intact after doping; the sensor reaches 21.2 Hz per % with three days of stability, and western blot confirms its readings, aiming at SMN measurements in blood plasma.

Summary written by the openQCM team. The original abstract is on the publisher’s page.

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