openQCM – Powered by Novaetech S.r.l
Publications citing the applications of openQCM (by Novaetech S.r.l.) instruments and accessories in scientific research.
The list of scientific papers published on the most important journals showing the usage of openQCM in several scientific fields, such as thin film deposition, chemical sensors, biological research and biosensors.
Because of the large number of publications, we are reorganizing everything by subject areas. This will take some time. Thank you for your patience
Sehit, Ekin; Yao, Guiyang; Battocchio, Giovanni; Radfar, Rahil; Trimpert, Jakob; Mroginski, Maria A; Süssmuth, Roderich; Altintas, Zeynep
In: ACS sensors, 2024.
Abstract | Links | BibTeX | Tags: Antigens, Drinking water, epitope imprinting, in silico-designed epitope-mediated adenovirus receptors, molecular dynamics, Monomers, openQCM Q-1, QCM, QCM sensor, Receptors, sensors, virus detection
@article{sehit2024computationally,
title = {Computationally Designed Epitope-Mediated Imprinted Polymers versus Conventional Epitope Imprints for the Detection of Human Adenovirus in Water and Human Serum Samples},
author = {Ekin Sehit and Guiyang Yao and Giovanni Battocchio and Rahil Radfar and Jakob Trimpert and Maria A Mroginski and Roderich Süssmuth and Zeynep Altintas},
url = {https://pubs.acs.org/doi/full/10.1021/acssensors.3c02374},
doi = {https://doi.org/10.1021/acssensors.3c02374},
year = {2024},
date = {2024-03-15},
urldate = {2024-03-15},
journal = {ACS sensors},
publisher = {ACS Publications},
abstract = {Detection of pathogenic viruses for point-of-care applications has attracted great attention since the COVID-19 pandemic. Current virus diagnostic tools are laborious and expensive, while requiring medically trained staff. Although user-friendly and cost-effective biosensors are utilized for virus detection, many of them rely on recognition elements that suffer major drawbacks. Herein, computationally designed epitope-imprinted polymers (eIPs) are conjugated with a portable piezoelectric sensing platform to establish a sensitive and robust biosensor for the human pathogenic adenovirus (HAdV). The template epitope is selected from the knob part of the HAdV capsid, ensuring surface accessibility. Computational simulations are performed to evaluate the conformational stability of the selected epitope. Further, molecular dynamics simulations are executed to investigate the interactions between the epitope and the different functional monomers for the smart design of eIPs. The HAdV epitope is imprinted via the solid-phase synthesis method to produce eIPs using in silico-selected ingredients. The synthetic receptors show a remarkable detection sensitivity (LOD: 102 pfu mL–1) and affinity (dissociation constant (Kd): 6.48 × 10–12 M) for HAdV. Moreover, the computational eIPs lead to around twofold improved binding behavior than the eIPs synthesized with a well-established conventional recipe. The proposed computational strategy holds enormous potential for the intelligent design of ultrasensitive imprinted polymer binders.},
keywords = {Antigens, Drinking water, epitope imprinting, in silico-designed epitope-mediated adenovirus receptors, molecular dynamics, Monomers, openQCM Q-1, QCM, QCM sensor, Receptors, sensors, virus detection},
pubstate = {published},
tppubtype = {article}
}
Brotherton, Emma E; Johnson, Edwin C; Smallridge, Mark J; Hammond, Deborah B; Leggett, Graham J; Armes, Steven P
Hydrophilic Aldehyde-Functional Polymer Brushes: Synthesis, Characterization, and Potential Bioapplications Journal Article
In: Macromolecules, 2023.
Abstract | Links | BibTeX | Tags: Functionalization, Monomers, peptides, proteins, QCM, Thickness, X-ray, X-ray photoelectron spectroscopy
@article{brotherton2023hydrophilic,
title = {Hydrophilic Aldehyde-Functional Polymer Brushes: Synthesis, Characterization, and Potential Bioapplications},
author = {Emma E Brotherton and Edwin C Johnson and Mark J Smallridge and Deborah B Hammond and Graham J Leggett and Steven P Armes},
url = {https://pubs.acs.org/doi/full/10.1021/acs.macromol.2c02471},
doi = {https://doi.org/10.1021/acs.macromol.2c02471},
year = {2023},
date = {2023-02-22},
urldate = {2023-01-01},
journal = {Macromolecules},
publisher = {ACS Publications},
abstract = {Surface-initiated activators regenerated by electron transfer atom transfer radical polymerization (ARGET ATRP) is used to polymerize a cis-diol-functional methacrylic monomer (herein denoted GEO5MA) from planar silicon wafers. Ellipsometry studies indicated dry brush thicknesses ranging from 40 to 120 nm. The hydrophilic PGEO5MA brush is then selectively oxidized using sodium periodate to produce an aldehyde-functional hydrophilic PAGEO5MA brush. This post-polymerization modification strategy provides access to significantly thicker brushes compared to those obtained by surface-initiated ARGET ATRP of the corresponding aldehyde-functional methacrylic monomer (AGEO5MA). The much slower brush growth achieved in the latter case is attributed to the relatively low aqueous solubility of the AGEO5MA monomer. X-ray photoelectron spectroscopy (XPS) analysis confirmed that precursor PGEO5MA brushes were essentially fully oxidized to the corresponding PAGEO5MA brushes within 30 min of exposure to a dilute aqueous solution of sodium periodate at 22 °C. PAGEO5MA brushes were then functionalized via Schiff base chemistry using an amino acid (histidine), followed by reductive amination with sodium cyanoborohydride. Subsequent XPS analysis indicated that the mean degree of histidine functionalization achieved under optimized conditions was approximately 81%. Moreover, an XPS depth profiling experiment confirmed that the histidine groups were uniformly distributed throughout the brush layer. Surface ζ potential measurements indicated a significant change in the electrophoretic behavior of the zwitterionic histidine-functionalized brush relative to that of the non-ionic PGEO5MA precursor brush. The former brush exhibited cationic character at low pH and anionic character at high pH, with an isoelectric point being observed at around pH 7. Finally, quartz crystal microbalance studies indicated minimal adsorption of a model globular protein (BSA) on a PGEO5MA brush-coated substrate, whereas strong protein adsorption via Schiff base chemistry occurred on a PAGEO5MA brush-coated substrate.},
key = {Functionalization,Monomers,Peptides and proteins,Thickness,X-ray photoelectron spectroscopy},
keywords = {Functionalization, Monomers, peptides, proteins, QCM, Thickness, X-ray, X-ray photoelectron spectroscopy},
pubstate = {published},
tppubtype = {article}
}
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