@article{khoirudin2023influence,

title = {Influence of the SMN antibody on quartz crystal microbalance with dissipation (QCM-D) surface as an SMN protein biosensor},

author = {Hanif Khoirudin and Rizky Aflaha and Eldiana Rully Arsetiyani and Ari Dwi Nugraheni and Dian Kesumapramudya Nurputra and Kuwat Triyana and Ahmad Kusumaatmaja},

year  = {2023},

date = {2023-11-06},

urldate = {2023-01-01},

journal = {MRS Communications},

pages = {1--7},

publisher = {Springer},

abstract = {The lack of survival motor neuron (SMN) protein levels can lead to spinal muscular atrophy (SMA) disease. In this study, an SMN protein biosensor based on quartz crystal microbalance with dissipation (QCM-D) was developed. The sensor was coated with polyvinyl alcohol (PVA) nanofiber and doped with SMN antibodies to increase the sensitivity. Scanning electron microscope (SEM) images showed that the nanofiber was undamaged after doping the SMN antibody. The sensitivity of the QCM-D sensor was 21.2 Hz/% after doping SMN antibodies and had good stability for 3 days. Moreover, the sensor has been validated using western blot. Thus, the fabricated QCM-D-based biosensor has excellent potential in detecting SMN levels in human blood plasma.},

key = {QCM-D, openQCM, Quartz Crystal Microbalance, neuron, protein, antibodies, nanofiber, SEM},

keywords = {antibody detection, Nanofiber, Nanofibers, neuron, openQCM, protein, QCM-D, Quartz Crystal Microbalance, SEM},

pubstate = {published},

tppubtype = {article}

}

@article{bulut2023novel,

title = {A Novel Peptide-Based Detection of SARS-CoV-2 Antibodies},

author = {Aliye Bulut and Betul Z Temur and Ceyhun E Kirimli and Ozgul Gok and Bertan K Balcioglu and Hasan U Ozturk and Neval Y Uyar and Zeynep Kanlidere and Tanil Kocagoz and Ozge Can},

url = {https://www.mdpi.com/2313-7673/8/1/89},

doi = {https://doi.org/10.3390/biomimetics8010089},

year  = {2023},

date = {2023-02-22},

urldate = {2023-02-22},

journal = {Biomimetics},

volume = {8},

number = {1},

pages = {89},

publisher = {MDPI},

abstract = {The need for rapidly developed diagnostic tests has gained significant attention after the recent pandemic. Production of neutralizing antibodies for vaccine development or antibodies to be used in diagnostic tests usually require the usage of recombinant proteins representing the infectious agent. However, peptides that can mimic these recombinant proteins may be rapidly utilized, especially in emergencies such as the recent outbreak. Here, we report two peptides that mimic the receptor binding domain of the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and investigate their binding behavior against the corresponding human immunoglobulin G and immunoglobulin M (IgG and IgM) antibodies in a clinical sample using a quartz crystal microbalance (QCM) sensor. These peptides were immobilized on a QCM sensor surface, and their binding behavior was studied against a clinical serum sample that was previously determined to be IgG and IgM-positive. It was determined that designed peptides bind to SARS-CoV-2 antibodies in a clinical sample. These peptides might be useful for the detection of SARS-CoV-2 antibodies using different methods such as enzyme-linked immunosorbent assay (ELISA) or lateral flow assays. A similar platform might prove to be useful for the detection and development of antibodies in other infections.},

key = {peptide mimetics, SARS-CoV-2, biosensor, quartz crystal microbalance, antibody detection},

keywords = {antibody detection, biosensors, peptide mimetics, QCM, Quartz Crystal Microbalance, SARS-CoV-2},

pubstate = {published},

tppubtype = {article}

}