openQCM – Powered by Novaetech S.r.l
Publications citing the applications of openQCM (by Novaetech S.r.l.) instruments and accessories in scientific research.
The list of scientific papers published on the most important journals showing the usage of openQCM in several scientific fields, such as thin film deposition, chemical sensors, biological research and biosensors.
Because of the large number of publications, we are reorganizing everything by subject areas. This will take some time. Thank you for your patience
Baruah, Susmita; Betty, CA
Point of care devices for detection of Covid-19, malaria and dengue infections: A review Journal Article
In: Bioelectrochemistry, pp. 108704, 2024.
Abstract | Links | BibTeX | Tags: Covid −19, Dengue, openQCM, POC diagnostic devices, QCM, Quartz Crystal Microbalance
@article{baruah2024point,
title = {Point of care devices for detection of Covid-19, malaria and dengue infections: A review},
author = {Susmita Baruah and CA Betty},
url = {https://www.sciencedirect.com/science/article/abs/pii/S1567539424000665},
doi = {https://doi.org/10.1016/j.bioelechem.2024.108704},
year = {2024},
date = {2024-08-01},
urldate = {2024-08-01},
journal = {Bioelectrochemistry},
pages = {108704},
publisher = {Elsevier},
abstract = {Need for affordable, rapid and user-friendly point of care (POC) devices are increasing exponentially for strengthening the health care system in primary care as well as for self- monitoring in routine analysis. In addition to routine analysis of glucose, Covid-19 type fast spreading, infectious diseases have created further push for exploring rapid, cost-effective and self-monitoring diagnostic devices. Successful implementation of self-monitoring devices for Covid −19 has been realized. However, not much success has been realized for malaria and dengue which are two fatal diseases that affect the population in underdeveloped and developing countries. To monitor the presence of parasites for these diseases, rapid, onsite monitoring devices are still being explored. In this review, we present a review of the research carried out on electrochemical POC devices for monitoring infectious diseases such as Covid-19, malaria and dengue.
},
keywords = {Covid −19, Dengue, openQCM, POC diagnostic devices, QCM, Quartz Crystal Microbalance},
pubstate = {published},
tppubtype = {article}
}
Al-Sodies, Salsabeel; Asiri, Abdullah M; Ismail, Sameh; Alamry, Khalid A; Abdo, Mahmoud Hussein
In: Materials Research Express, 2024.
Abstract | Links | BibTeX | Tags: contamination, Drinking water, GNPs (Graphene Nanoplatelets), MWCNTs (Multi-Walled Carbon Nanotubes), Nanocomposites, openQCM sensors, Poly(phenosafranine), Poly(safranine), QCM, Quartz Crystal Microbalance
@article{al2024development,
title = {Development of Poly (safranine-co-phenosafranine)/GNPs/MWCNTs Nanocomposites for Quartz Crystal Microbalance Sensor Detection of Arsenic (III) Ions},
author = {Salsabeel Al-Sodies and Abdullah M Asiri and Sameh Ismail and Khalid A Alamry and Mahmoud Hussein Abdo},
url = {https://iopscience.iop.org/article/10.1088/2053-1591/ad37a5/meta},
year = {2024},
date = {2024-04-12},
urldate = {2024-04-12},
journal = {Materials Research Express},
abstract = {Contamination of drinking water by heavy metals is extremely dangerous to human health. The formation of a quartz crystal microbalance (QCM) sensor for the rapid and portable detection of harmful heavy metals such as arsenic (As) ions in water samples is detailed in this work. Equimolar ratios of safranine (SF) and phenosafranine (Ph) copolymers (PSF-Ph) were synthesized via a chemical oxidative polymerization approach. The copolymer was modified with multi-wall carbon nanotubes (MWCNTs) and graphene nanoplatelets (GNPs) at different percentages (1, 3, 5, and 10%) to form nanocomposites of PSF-Ph/MWCNTs/GNPs. Thermal analysis of the nanocomposites revealed that the final polymer decomposition temperature (PDTfinal) values fell between 619 and 630 °C, and the nanocomposite with 10% loading exhibited the highest decomposition temperatures for T10, T30, and T50. The nanohybrid QCM sensor detected As(III) down to parts-per-billion levels based on the change in the oscillation frequency. The sensor was tested on water samples spiked with different concentrations of As(III) (0–20 ppb). A strong linear correlation (R2 ≈ 0.99) between the frequency shift and concentration with a low detection limit (0.1 ppb) validated the quantitative detection capability of the sensor. This QCM platform with an optimal recognition ligand is a promising field-deployable tool for on-site arsenic analysis in water.},
keywords = {contamination, Drinking water, GNPs (Graphene Nanoplatelets), MWCNTs (Multi-Walled Carbon Nanotubes), Nanocomposites, openQCM sensors, Poly(phenosafranine), Poly(safranine), QCM, Quartz Crystal Microbalance},
pubstate = {published},
tppubtype = {article}
}
Haldar, Ritesh; Maity, Tanmoy; Sarkar, Susmita; Kundu, Susmita; Panda, Suvendu; Sarkar, Arighna; Mandal, Kalyaneswar; Ghosh, Soumya; Mondal, Jagannath
Steering diffusion selectivity of chemical isomers within aligned nanochannels of metal-organic framework thin film Journal Article
In: 2024.
Abstract | Links | BibTeX | Tags: Metal organic frameworks, MOFs, molecular diffusion, nanoporous materials, openQCM sensors, QCM, Quartz Crystal Microbalance
@article{haldar2024steering,
title = {Steering diffusion selectivity of chemical isomers within aligned nanochannels of metal-organic framework thin film},
author = {Ritesh Haldar and Tanmoy Maity and Susmita Sarkar and Susmita Kundu and Suvendu Panda and Arighna Sarkar and Kalyaneswar Mandal and Soumya Ghosh and Jagannath Mondal},
url = {https://www.researchsquare.com/article/rs-4046811/v1},
doi = {https://doi.org/10.21203/rs.3.rs-4046811/v1},
year = {2024},
date = {2024-03-21},
urldate = {2024-03-21},
abstract = {The movement of molecules (i.e. diffusion) within angstrom-scale pores of porous materials such as metal-organic frameworks (MOFs) and zeolites is influenced by multiple complex factors that can be challenging to assess and manipulate. Nevertheless, understanding and controlling this diffusion phenomenon is crucial for advancing energy-economic membrane-based chemical separation technologies, as well as for heterogeneous catalysis and sensing applications. Through precise assessment of the factors influencing diffusion within a porous metal-organic framework (MOF) thin film, we have developed a chemical strategy to manipulate and reverse chemical isomer diffusion selectivity. In the process of cognizing the molecular diffusion within oriented, angstrom-scale channels of MOF thin film, we have unveiled a dynamic chemical interaction between the adsorbate (chemical isomers) and the MOF using a combination of kinetic mass uptake experiments and molecular simulation. Leveraging the dynamic chemical interactions, we have reversed the haloalkane (positional) isomer diffusion selectivity, forging a novel chemical pathway to elevate the overall efficacy of membrane-based chemical separation and selective catalytic reactions.},
keywords = {Metal organic frameworks, MOFs, molecular diffusion, nanoporous materials, openQCM sensors, QCM, Quartz Crystal Microbalance},
pubstate = {published},
tppubtype = {article}
}
Kunčák, Jakub; Forinová, Michala; Pilipenco, Alina; Procházka, Viktor; Horák, Petr; Dmitrievna, Sycheva Sofya; Deyneka, Ivan Gennadievich; Vaisocherová-L'isalová, Hana
In: Available at SSRN 4756321, 2024.
Abstract | Links | BibTeX | Tags: automatic data classification, Detection of pathogens, E. coli O157:H7, openQCM, openQCM Q-1, Point-of-care biosensors, Quartz Crystal Microbalance, SARS-CoV-2
@article{kunvcak2024automating,
title = {Automating Data Analysis for Point-of-Care Label-Free Surface-Based Affinity Biosensors Dealing with Complex Biological Samples: Escherichia Coli O157: H7 and Sars-Cov-2 Case Studies},
author = {Jakub Kunčák and Michala Forinová and Alina Pilipenco and Viktor Procházka and Petr Horák and Sycheva Sofya Dmitrievna and Ivan Gennadievich Deyneka and Hana Vaisocherová-L'isalová},
url = {https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4756321},
year = {2024},
date = {2024-03-20},
urldate = {2024-03-20},
journal = {Available at SSRN 4756321},
abstract = {Surface-based affinity biosensors offer a promising avenue for point-of-care (POC) detection of pathogens in real-world samples. While laboratory-based devices commonly employ various techniques to compensate for noise, signal drifts, fluidic artifacts, and other system imperfections, their POC counterparts aiming at providing simple cost-effective detection platforms for field use, often lack these qualities. This paper addresses this gap by introducing a procedure for automatic classification of pathogen presence in unprocessed liquids from direct detection data measured by a simple POC-relevant quartz crystal microbalance sensor device. By considering the nature of the sensor signal and the sources of its imperfections in real-world media, a straightforward procedure integrates “classical” analytical tools (filtering, data selection, baseline de-drifting, and result calculation) in successive steps to automate sample classification without the need for extensive machine learning. Through optimizing parameters using diverse datasets encompassing Escherichia coli O157:H7 (E. coli) and SARS-CoV-2 detection in various media including food-derived matrices and cell culture media, we achieved rates of successful detection as high as 80.8% and 90.9% for E. coli and SARS-CoV-2, respectively. Furthermore, we analyse the sensitivity of the routine to variations of input parameters and with examples discuss the key factors influencing the accuracy of the overall procedure. The results show that the developed method exhibits exceptional robustness across different biosensing assays and complex real-world media, highlighting its promising broader applicability in point-of-care diagnostics.},
keywords = {automatic data classification, Detection of pathogens, E. coli O157:H7, openQCM, openQCM Q-1, Point-of-care biosensors, Quartz Crystal Microbalance, SARS-CoV-2},
pubstate = {published},
tppubtype = {article}
}
Skládal, Petr
Piezoelectric biosensors: shedding light on principles and applications Journal Article
In: Microchimica Acta, vol. 191, no. 4, pp. 184, 2024.
Abstract | Links | BibTeX | Tags: Cellular biosensors, Combined biosensing set-ups, Enzyme activity, Immunosensors, Microbial detection, openQCM, QCM, Quartz Crystal Microbalance
@article{skladal2024piezoelectric,
title = {Piezoelectric biosensors: shedding light on principles and applications},
author = {Petr Skládal},
url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10920441/},
doi = {https://doi.org/10.1007%2Fs00604-024-06257-9},
year = {2024},
date = {2024-03-07},
urldate = {2024-03-07},
journal = {Microchimica Acta},
volume = {191},
number = {4},
pages = {184},
publisher = {Springer},
abstract = {The three decades of experience with piezoelectric devices applied in the field of bioanalytical chemistry are shared. After introduction to principles and suitable measuring approaches, active and passive methods based on oscillators and impedance analysis, respectively, the focus is directed towards biosensing approaches. Immunosensing examples are provided, followed by other affinity sensing approaches based on hybridization of nucleic acids, aptamers, monitoring of enzyme activities, and detection of pathogenic microbes. The combination of piezosensors with cell lines and testing of drugs is highlighted, including mechanically active cells. The combination of piezosensors with other measuring techniques providing original hybrid devices is briefly discussed.},
keywords = {Cellular biosensors, Combined biosensing set-ups, Enzyme activity, Immunosensors, Microbial detection, openQCM, QCM, Quartz Crystal Microbalance},
pubstate = {published},
tppubtype = {article}
}
Razib, Mohd Asyraf Mohd; Mahadi, Aisyah Syafiqah; Ralib, Aliza Aini Md; Yusoff, Marmeezee Mohd; Ahmad, Farah B.
2024.
Abstract | Links | BibTeX | Tags: Biosensor, Carbon Nanotubes, openQCM Software, QCM, Quartz Crystal Microbalance, Sensing Layer
@bachelorthesis{nokey,
title = {Synthesis and Characterization of Multi-Walled Carbon Nanotube/Chitosan (Mwcnt/Cs) Composite as a Sensing Layer on Quartz Crystal Microbalance (Qcm) for Detection of Volatile Organic Compounds (Vocs)},
author = {Mohd Asyraf Mohd Razib and Aisyah Syafiqah Mahadi and Aliza Aini Md Ralib and Marmeezee Mohd Yusoff and Farah B. Ahmad},
url = {https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4727417},
year = {2024},
date = {2024-02-15},
urldate = {2024-02-15},
abstract = {Quartz crystal microbalance (QCM) is a sensor that can detect changes in nanogram mass. QCM alone is inadequate for detecting volatile organic compounds (VOCs) as it lacks sensitivity and selectivity for a gas sensor; thus, various sensing layers were suggested to be deposited. This study introduces multi-walled carbon nanotubes (MWCNT) and chitosan (CS) composite as a potential new sensing material. MWCNT has the advantage of a large surface area, improving the adsorption of gases. At the same time, CS is a natural biopolymer with a high affinity with VOCs as it is very hydrophilic. Harnessing advantages over both materials can study the response in profiling selective VOCs. Studies were conducted through the characterization of nanocomposite using Raman spectroscopy, Fourier Transform Infrared (FTIR) spectroscopy, and Scanning Electron Microscopy (SEM) to determine the properties of the MWCNT/CS composite on QCM toward VOCs. MWCNT/CS was prepared using glutaraldehyde as a cross-linker to form a covalent bond between MWCNT and CS via sonication. CS, MWCNT, and the composite were prepared for characterization analysis. The result of FTIR spectroscopy of MWCNT/CS showed NH2, C=O, and C-N bond at 3359.45 cm-1, 2160.51-2033.71 cm-1, and 1074.25 cm-1, respectively, showing that the functional group in CS was presented in the composite. The surface morphology of the MWCNTs/CS was detected using SEM. QCM sensor with gold electrodes was fabricated by drop-casting the composite on the working electrode of the QCM. Next, an adsorption test was conducted to study the sensitivity of the composite as the sensing layer using isopropyl alcohol (IPA, 13.1 M) as VOCs. The frequency shift of the IPA adsorption for the MWCNT/CS-based sensor was 95.2 Hz with a response time of 42s. The result shows that the MWCNT/CS can be a potential sensing layer to detect VOCs.},
keywords = {Biosensor, Carbon Nanotubes, openQCM Software, QCM, Quartz Crystal Microbalance, Sensing Layer},
pubstate = {published},
tppubtype = {bachelorthesis}
}
Chen, Xie
QCM anal`yza nanočástic a molekul Masters Thesis
České vysoké učen'i technické v Praze. Vypočetn'i a informačn'i centrum., 2024.
Abstract | Links | BibTeX | Tags: Cortisol, nanodiamonds, nanoparticles, openQCM Q-1, QCM-D, Quartz Crystal Microbalance
@mastersthesis{chen2024qcm,
title = {QCM anal`yza nanočástic a molekul},
author = {Xie Chen},
url = {https://dspace.cvut.cz/handle/10467/113400},
year = {2024},
date = {2024-01-22},
urldate = {2024-01-22},
school = {České vysoké učen'i technické v Praze. Vypočetn'i a informačn'i centrum.},
abstract = {Sensors based on quartz crystal microbalances (QCM) have dominated research in recent years. They have produced excellent laboratory results in analyzing the mass as well as the conformation of nanoparticles and molecules. The technology is constantly developed and widely used in various fields of chemistry, physics and biology. Here, we investigated a novel concept based on the use of nanodiamonds on QCM and explored the performance of nanodiamonds on QCM sensors, which helps in expanding the application of nanodiamonds in biosensing and exploring their effectiveness in QCM setups. We established a procedure and suitable parameters for the QCM sensor measurement. 5 MHz opensource QCM sensor system was used for building up the sensor assay for detection of cortisol via antigen (Ag)-antibody (Ab) reactions. Optical pictures after each functionalization step as well as scanning electron microscopy (SEM) pictures before and after the experiment were observed and compared. The values of amplitude, phase, resonance frequency, and dissipation were acquired in dry and water environment. The main evaluated QCM parameters were changes in resonance frequency (Δf) and simultaneous changes in QCM energy dissipation (ΔD), corresponding to changes in mass and morphology of the investigated sensor structure. Thereby we identified sensor assay build up, its functioning in dry and water conditions as well as potential issues such as partial release of nanodiamonds during the chemical treatments.
Sensors based on quartz crystal microbalances (QCM) have dominated research in recent years. They have produced excellent laboratory results in analyzing the mass as well as the conformation of nanoparticles and molecules. The technology is constantly developed and widely used in various fields of chemistry, physics and biology. Here, we investigated a novel concept based on the use of nanodiamonds on QCM and explored the performance of nanodiamonds on QCM sensors, which helps in expanding the application of nanodiamonds in biosensing and exploring their effectiveness in QCM setups. We established a procedure and suitable parameters for the QCM sensor measurement. 5 MHz opensource QCM sensor system was used for building up the sensor assay for detection of cortisol via antigen (Ag)-antibody (Ab) reactions. Optical pictures after each functionalization step as well as scanning electron microscopy (SEM) pictures before and after the experiment were observed and compared. The values of amplitude, phase, resonance frequency, and dissipation were acquired in dry and water environment. The main evaluated QCM parameters were changes in resonance frequency (Δf) and simultaneous changes in QCM energy dissipation (ΔD), corresponding to changes in mass and morphology of the investigated sensor structure. Thereby we identified sensor assay build up, its functioning in dry and water conditions as well as potential issues such as partial release of nanodiamonds during the chemical treatments.},
keywords = {Cortisol, nanodiamonds, nanoparticles, openQCM Q-1, QCM-D, Quartz Crystal Microbalance},
pubstate = {published},
tppubtype = {mastersthesis}
}
Forinová, Michala; Seidlová, Anna; Pilipenco, Alina; Jr, N Scott Lynn; Obořilová, Radka; Farka, Zdeněk; Skládal, Petr; Saláková, Alena; Spasovová, Monika; Houska, Milan; others,
In: Current Research in Biotechnology, pp. 100166, 2023.
Abstract | Links | BibTeX | Tags: Antifouling coating, biosensors, Cultivation-based methods, openQCM Q-1, QCM-D, Quartz Crystal Microbalance, S. aureus
@article{forinova2023comparative,
title = {A Comparative Assessment of a Piezoelectric Biosensor Based on a New Antifouling Nanolayer and Cultivation Methods: Enhancing S. aureus Detection in Fresh Dairy Products},
author = {Michala Forinová and Anna Seidlová and Alina Pilipenco and N Scott Lynn Jr and Radka Obořilová and Zdeněk Farka and Petr Skládal and Alena Saláková and Monika Spasovová and Milan Houska and others},
url = {https://www.sciencedirect.com/science/article/pii/S2590262823000485},
doi = {https://doi.org/10.1016/j.crbiot.2023.100166},
year = {2023},
date = {2023-11-23},
urldate = {2023-11-23},
journal = {Current Research in Biotechnology},
pages = {100166},
publisher = {Elsevier},
abstract = {Ensuring dairy product safety demands rapid and precise Staphylococcus aureus (S. aureus) detection. Biosensors show promise, but their performance is often demonstrated in model samples using non-native pathogens and has never been studied towards S. aureus detection in naturally contaminated samples. This study addresses the gap by directly comparing results taken with a novel piezoelectric biosensor, capable of one-step detection, with four conventional cultivation-based methods. Our findings reveal that this biosensor, based on an antifouling nanolayer-coated biochip, exhibits exceptional resistance to biofouling from unprocessed dairy products and is further capable of specific S. aureus detection. Notably, it performed comparably to Petrifilm and Baird-Parker methods but delivered results in only 30 min, bringing a substantial reduction from the 24 h required by cultivation-based techniques. Our study also highlights differences in the performance of cultivation methods when analyzing artificially spiked versus naturally contaminated foods. These findings underline the potential of antifouling biosensors as efficient reliable tools for rapid, cost-effective, point-of-care testing, enhancing fresh dairy product safety and S. aureus detection.},
keywords = {Antifouling coating, biosensors, Cultivation-based methods, openQCM Q-1, QCM-D, Quartz Crystal Microbalance, S. aureus},
pubstate = {published},
tppubtype = {article}
}
Khoirudin, Hanif; Aflaha, Rizky; Arsetiyani, Eldiana Rully; Nugraheni, Ari Dwi; Nurputra, Dian Kesumapramudya; Triyana, Kuwat; Kusumaatmaja, Ahmad
Influence of the SMN antibody on quartz crystal microbalance with dissipation (QCM-D) surface as an SMN protein biosensor Journal Article
In: MRS Communications, pp. 1–7, 2023.
Abstract | BibTeX | Tags: antibody detection, Nanofiber, Nanofibers, neuron, openQCM, protein, QCM-D, Quartz Crystal Microbalance, SEM
@article{khoirudin2023influence,
title = {Influence of the SMN antibody on quartz crystal microbalance with dissipation (QCM-D) surface as an SMN protein biosensor},
author = {Hanif Khoirudin and Rizky Aflaha and Eldiana Rully Arsetiyani and Ari Dwi Nugraheni and Dian Kesumapramudya Nurputra and Kuwat Triyana and Ahmad Kusumaatmaja},
year = {2023},
date = {2023-11-06},
urldate = {2023-01-01},
journal = {MRS Communications},
pages = {1--7},
publisher = {Springer},
abstract = {The lack of survival motor neuron (SMN) protein levels can lead to spinal muscular atrophy (SMA) disease. In this study, an SMN protein biosensor based on quartz crystal microbalance with dissipation (QCM-D) was developed. The sensor was coated with polyvinyl alcohol (PVA) nanofiber and doped with SMN antibodies to increase the sensitivity. Scanning electron microscope (SEM) images showed that the nanofiber was undamaged after doping the SMN antibody. The sensitivity of the QCM-D sensor was 21.2 Hz/% after doping SMN antibodies and had good stability for 3 days. Moreover, the sensor has been validated using western blot. Thus, the fabricated QCM-D-based biosensor has excellent potential in detecting SMN levels in human blood plasma.},
key = {QCM-D, openQCM, Quartz Crystal Microbalance, neuron, protein, antibodies, nanofiber, SEM},
keywords = {antibody detection, Nanofiber, Nanofibers, neuron, openQCM, protein, QCM-D, Quartz Crystal Microbalance, SEM},
pubstate = {published},
tppubtype = {article}
}
Muff, Livius F; Balog, Sandor; Adamcik, Jozef; Weder, Christoph; Lehner, Roman
Preparation of Well-Defined Fluorescent Nanoplastic Particles by Confined Impinging Jet Mixing Journal Article
In: Environmental Science & Technology, 2023.
Abstract | Links | BibTeX | Tags: confined impinging jet (CIJ) mixer, flash nanoprecipitation, fluorescent label, fluorophore, nanoemulsion, nanoplastic, openQCM, polymer nanoparticles, QCM, Quartz Crystal Microbalance, shape modification
@article{muff2023preparation,
title = {Preparation of Well-Defined Fluorescent Nanoplastic Particles by Confined Impinging Jet Mixing},
author = {Livius F Muff and Sandor Balog and Jozef Adamcik and Christoph Weder and Roman Lehner},
url = {https://link.springer.com/article/10.1557/s43579-023-00492-6},
doi = {https://doi.org/10.1557/s43579-023-00492-6},
year = {2023},
date = {2023-11-01},
urldate = {2023-11-01},
journal = {Environmental Science & Technology},
publisher = {ACS Publications},
abstract = {Research on the origin, distribution, detection, identification, and quantification of polymer nanoparticles (NPs) in the environment and their possible impact on animal and human health is surging. For different types of studies in this field, well-defined reference materials or mimics are needed. While isolated reports on the preparation of such materials are available, a simple and broadly applicable method that allows for the production of different NP types with well-defined, tailorable characteristics is still missing. Here, we demonstrate that a confined impinging jet mixing process can be used to prepare colloidally stable NPs based on polystyrene, polyethylene, polypropylene, and poly(ethylene terephthalate) with diameters below < 100 nm. Different fluorophores were incorporated into the NPs, to allow their detection in complex environments. To demonstrate their utility and detectability, fluorescent NPs were exposed to J774A.1 macrophages and visualized using laser scanning microscopy. Furthermore, we modified the NPs in a postfabrication process and changed their shape from spherical to heterogeneous geometries, in order to mimic environmentally relevant morphologies. The methodology used here should be readily applicable to other polymers and payloads and thus a broad range of NPs that enable studies of their behavior, uptake, translocation, and biological end points in different systems.},
key = {QC; openQCM, Quartz Crystal Microbalance},
keywords = {confined impinging jet (CIJ) mixer, flash nanoprecipitation, fluorescent label, fluorophore, nanoemulsion, nanoplastic, openQCM, polymer nanoparticles, QCM, Quartz Crystal Microbalance, shape modification},
pubstate = {published},
tppubtype = {article}
}
Milsom, Adam; Qi, Shaojun; Mishra, Ashmi; Berkemeier, Thomas; Zhang, Zhenyu; Pfrang, Christian
In: EGUsphere, vol. 23, iss. 19, pp. 10835–10843, 2023.
Abstract | Links | BibTeX | Tags: aerosol, Dissipation Monitoring, films, openQCM NEXT, Ozone, pollutants, pollution, QCM, QCM-D, Quartz Crystal Microbalance
@article{milsom2023situ,
title = {In-situ measurements and modelling of the oxidation kinetics in films of a cooking aerosol proxy using a Quartz Crystal Microbalance with Dissipation monitoring (QCM-D)},
author = {Adam Milsom and Shaojun Qi and Ashmi Mishra and Thomas Berkemeier and Zhenyu Zhang and Christian Pfrang},
url = {https://acp.copernicus.org/articles/23/10835/2023/},
doi = {https://doi.org/10.5194/acp-23-10835-2023},
year = {2023},
date = {2023-10-04},
urldate = {2023-10-04},
journal = {EGUsphere},
volume = {23},
issue = {19},
pages = {10835–10843},
publisher = {Copernicus Publications Göttingen, Germany},
abstract = {Aerosols and films are found in indoor and outdoor environments. How they interact with pollutants, such as ozone, has a direct impact on our environment via cloud droplet formation and the chemical persistence of toxic aerosol constituents. The chemical reactivity of aerosol emissions is typically measured spectroscopically or by techniques such as mass spectrometry, directly monitoring the amount of material during a chemical reaction. We present a study which indirectly measures oxidation kinetics in a common cooking aerosol proxy using a low-cost quartz crystal microbalance with dissipation monitoring (QCM-D). We validated this approach by comparison with kinetics measured both spectroscopically and with high-intensity synchrotron radiation. Using microscopy, we found that the film morphology changed and film rigidity increased during oxidation. There was evidence of surface crust formation on oxidised particles, though this was not consistent for all experiments. Crucially, our kinetic modelling of these experimental data confirmed that the oleic acid decay rate is in line with previous literature determinations, which demonstrates that performing such experiments on a QCM-D does not alter the underlying mechanism. There is clear potential to take this robust and low-cost but sensitive method to the field for in situ monitoring of reactions outdoors and indoors.},
keywords = {aerosol, Dissipation Monitoring, films, openQCM NEXT, Ozone, pollutants, pollution, QCM, QCM-D, Quartz Crystal Microbalance},
pubstate = {published},
tppubtype = {article}
}
Aflaha, Rizky; Sari, Nur Laili Indah; Katriani, Laila; ari, Ahmad Hasan As'; Kusumaatmaja, Ahmad; Rianjanu, Aditya; Roto, Roto; Wasisto, Hutomo Suryo; Triyana, Kuwat
Maltodextrin-overlaid polyvinyl acetate nanofibers for highly sensitive and selective room-temperature ammonia sensors Journal Article
In: Microchemical Journal, pp. 109237, 2023.
Abstract | Links | BibTeX | Tags: 10 MHz, Ammonia, Nanofibers, openQCM sensors, Polyvinyl acetate, QCM, Quartz Crystal Microbalance
@article{aflaha2023maltodextrin,
title = {Maltodextrin-overlaid polyvinyl acetate nanofibers for highly sensitive and selective room-temperature ammonia sensors},
author = {Rizky Aflaha and Nur Laili Indah Sari and Laila Katriani and Ahmad Hasan As' ari and Ahmad Kusumaatmaja and Aditya Rianjanu and Roto Roto and Hutomo Suryo Wasisto and Kuwat Triyana},
url = {https://www.sciencedirect.com/science/article/abs/pii/S0026265X23008561},
doi = {https://doi.org/10.1016/j.microc.2023.109237},
year = {2023},
date = {2023-10-01},
urldate = {2023-10-01},
journal = {Microchemical Journal},
pages = {109237},
publisher = {Elsevier},
abstract = {Various ammonia sensors based on different materials have continuously been developed and employed to enable real-time monitoring of ammonia gas in the environment. Efforts are put not only to improve their sensitivity and selectivity towards the target gas but also to operate them at room temperature. Here, we investigated the effect of overlaying maltodextrin with different concentrations on the surface of polyvinyl acetate (PVAc) nanofibers on ammonia sensing performances, in which quartz crystal microbalance (QCM) was utilized as a transducer to measure the resonance frequency shift affected by the adsorbed gas molecules. Higher concentrations of the overlaying maltodextrin led to larger nanofiber diameter and more functional active groups on the active nanofibrous layers. PVAc nanofibers with 0.05% maltodextrin overlay demonstrated the highest sensitivity of 0.525 Hz·ppm−1 at room temperature, which was 6.4 times higher than their bare counterpart (nanofiber without maltodextrin overlay). That sensor also possessed fast response and recovery times of 32 s and 17 s with a low detection limit (1.92 ppm). Besides its high reproducibility, reversibility, and repeatability, the sensor exhibited outstanding selectivity to other gas analytes and good long-term stability for 32 days of testing. This research shows that maltodextrin overlay can be used as a low-cost alternative route to increase the performance of organic material-based ammonia sensors, especially polymer nanofibers.},
key = {QCM, 10 MHz, QCM sensors, polyvinyl acetate, nanofibers, ammonia},
keywords = {10 MHz, Ammonia, Nanofibers, openQCM sensors, Polyvinyl acetate, QCM, Quartz Crystal Microbalance},
pubstate = {published},
tppubtype = {article}
}
Jang, Il Ryu; Hajra, Sugato; Sahu, Rojalin; Kim, Hoe Joon
Heated quartz crystal microbalance with highly controlled integration of ZIF-67 for ultra-reliable humidity sensing Journal Article
In: Sensors and Actuators B: Chemical, pp. 134589, 2023, ISSN: 0925-4005.
Abstract | Links | BibTeX | Tags: 10 MHz, metal-organic framework, microheater, openQCM sensors, Quartz Crystal Microbalance, sensor calibration, ZIF-67
@article{JANG2023134589,
title = {Heated quartz crystal microbalance with highly controlled integration of ZIF-67 for ultra-reliable humidity sensing},
author = {Il Ryu Jang and Sugato Hajra and Rojalin Sahu and Hoe Joon Kim},
url = {https://www.sciencedirect.com/science/article/pii/S0925400523013047},
doi = {https://doi.org/10.1016/j.snb.2023.134589},
issn = {0925-4005},
year = {2023},
date = {2023-09-09},
urldate = {2023-01-01},
journal = {Sensors and Actuators B: Chemical},
pages = {134589},
abstract = {The quartz crystal microbalance (QCM) is widely utilized in various fields for detecting parameters such as relative humidity (RH). However, the reliability of QCM as an RH sensor can be compromised by the nonuniform integration of sensing materials and the absence of a dehumidification system for calibration. Damping of the sensor performance may occur due to excessive water molecule adsorption on agglomerated sensing materials, while ineffective desorption of water molecules from these materials renders QCM-based humidity sensors unreliable in highly humid environments. This study presents an innovative approach to achieve area-specific and highly-controlled integration of ZIF-67 on a quartz crystal microbalance (QCM) using electrospray deposition (ESD). The proposed method effectively decorates the sensor surface with exceptional picogram (pg) mass resolution. Additionally, an integrated microheater facilitates rapid sensor heating, eliminating residual water molecules and enhancing the proposed self-recalibration method. The comparative analysis demonstrates that the heated sensor exhibits a remarkable improvement of 47 times in hysteresis and 8 times in drift performance compared to the non-heated sensor. These findings hold great promise for enhancing the reliability of QCM-based humidity sensors, thereby finding utility in diverse research and application fields.},
keywords = {10 MHz, metal-organic framework, microheater, openQCM sensors, Quartz Crystal Microbalance, sensor calibration, ZIF-67},
pubstate = {published},
tppubtype = {article}
}
Aflaha, Rizky; Katriani, Laila; ari, Ahmad Hasan As’; Sari, Nur Laili Indah; Kusumaatmaja, Ahmad; Rianjanu, Aditya; Roto, Roto; Triyana, Kuwat
Enhanced trimethylamine gas sensor sensitivity based on quartz crystal microbalance using nanofibers overlaid with maltodextrin Journal Article
In: MRS Communications, pp. 1–9, 2023.
Abstract | Links | BibTeX | Tags: openQCM, openQCM sensors, QCM, Quartz Crystal Microbalance
@article{aflaha2023enhanced,
title = {Enhanced trimethylamine gas sensor sensitivity based on quartz crystal microbalance using nanofibers overlaid with maltodextrin},
author = {Rizky Aflaha and Laila Katriani and Ahmad Hasan As’ ari and Nur Laili Indah Sari and Ahmad Kusumaatmaja and Aditya Rianjanu and Roto Roto and Kuwat Triyana},
url = {https://link.springer.com/article/10.1557/s43579-023-00409-3},
doi = {https://doi.org/10.1557/s43579-023-00409-3},
year = {2023},
date = {2023-08-03},
urldate = {2023-08-03},
journal = {MRS Communications},
pages = {1--9},
publisher = {Springer},
abstract = {This study proposes a novel quartz crystal microbalance-based sensor using polyvinyl acetate nanofibers overlaid with maltodextrin to enhance sensitivity toward trimethylamine (TMA) gas. The sensor demonstrated a remarkable increase in sensitivity by 8.3 times, with a detection limit of 15.6 ppm. The enhanced sensitivity is due to reversible intermolecular Lewis acid–base interaction between active groups of maltodextrin and TMA gas molecules. Moreover, the sensor exhibited good selectivity, stability, and fast response and recovery times of 141 s and 116 s, respectively. The proposed sensor offers a promising alternative to conventional methods for accurately monitoring TMA gas levels in the air.},
key = {openqCM, QCM , quartz Crystal Microbalance openQCM sensors},
keywords = {openQCM, openQCM sensors, QCM, Quartz Crystal Microbalance},
pubstate = {published},
tppubtype = {article}
}
Hunter, Saul J; Elella, Mahmoud H Abu; Johnson, Edwin C; Taramova, Laura; Brotherton, Emma E; Armes, Steven P; Khutoryanskiy, Vitaliy V; Smallridge, Mark J
Mucoadhesive Pickering Nanoemulsions via Dynamic Covalent Chemistry Journal Article
In: Journal of Colloid and Interface Science, 2023.
Abstract | Links | BibTeX | Tags: Aldehyde-Functionalized Nanoparticles, Mucoadhesive Drug, Nanoemulsions, openQCM NEXT, QCM-D, Quartz Crystal Microbalance
@article{hunter2023mucoadhesive,
title = {Mucoadhesive Pickering Nanoemulsions via Dynamic Covalent Chemistry},
author = {Saul J Hunter and Mahmoud H Abu Elella and Edwin C Johnson and Laura Taramova and Emma E Brotherton and Steven P Armes and Vitaliy V Khutoryanskiy and Mark J Smallridge},
url = {https://www.sciencedirect.com/science/article/pii/S0021979723014200},
doi = {https://doi.org/10.1016/j.jcis.2023.07.162},
year = {2023},
date = {2023-07-27},
urldate = {2023-07-27},
journal = {Journal of Colloid and Interface Science},
publisher = {Elsevier},
abstract = {Hypothesis. Submicron oil droplets stabilized using aldehyde-functionalized nanoparticles should adhere to the primary amine groups present at the surface of sheep nasal mucosal tissue via Schiff base chemistry. Experiments. Well-defined sterically-stabilized diblock copolymer nanoparticles of 20 nm diameter were prepared in the form of concentrated aqueous dispersions via reversible addition-fragmentation chain transfer (RAFT) aqueous emulsion polymerization of 2,2,2-trifluoroethyl methacrylate (TFEMA) using a water-soluble methacrylic precursor bearing cis-diol groups. Some of these hydroxyl-functional nanoparticles were then selectively oxidized using an aqueous solution of sodium periodate to form a second batch of nanoparticles bearing pendent aldehyde groups within the steric stabilizer chains. Subjecting either hydroxyl- or aldehyde-functional nanoparticles to high-shear homogenization with a model oil (squalane) produced oil-in-water Pickering macroemulsions of 20-30 µm diameter. High-pressure microfluidization of such macroemulsions led to formation of the corresponding Pickering nanoemulsions with a mean droplet diameter of around 200 nm. Quartz crystal microbalance (QCM) experiments were used to examine adsorption of both nanoparticles and oil droplets onto a model planar substrate bearing primary amine groups, while a fluorescence microscopy-based mucoadhesion assay was developed to assess adsorption of the oil droplets onto sheep nasal mucosal tissue. Findings. Squalane droplets coated with aldehyde-functional nanoparticles adhered significantly more strongly to sheep nasal mucosal tissue than those coated with the corresponding hydroxyl-functional nanoparticles. This difference was attributed to the formation of surface imine bonds via Schiff base chemistry and was also observed for the two types of nanoparticles alone in QCM studies. Preliminary biocompatibility studies using planaria indicated only mild toxicity for these new mucoadhesive Pickering nanoemulsions, suggesting potential applications for the localized delivery of hydrophobic drugs.},
keywords = {Aldehyde-Functionalized Nanoparticles, Mucoadhesive Drug, Nanoemulsions, openQCM NEXT, QCM-D, Quartz Crystal Microbalance},
pubstate = {published},
tppubtype = {article}
}
Sukowati, Riris; Rohman, Yadi Mulyadi; Agung, Bertolomeus Haryanto; Hapidin, Dian Ahmad; Damayanti, Herlina; Khairurrijal, Khairurrijal
In: Sensors and Actuators B: Chemical, vol. 386, pp. 133708, 2023.
Abstract | Links | BibTeX | Tags: ethanol vapor, Nanofibers, openQCM Wi2, polyvinylpyrrolidone, QCM, Quartz Crystal Microbalance
@article{Sukowati_Rohman_Agung_Hapidin_Damayanti_Khairurrijal_2023,
title = {An investigation of the influence of nanofibers morphology on the performance of QCM-based ethanol vapor sensor utilizing polyvinylpyrrolidone nanofibers active layer},
author = {Riris Sukowati and Yadi Mulyadi Rohman and Bertolomeus Haryanto Agung and Dian Ahmad Hapidin and Herlina Damayanti and Khairurrijal Khairurrijal},
url = {https://www.sciencedirect.com/science/article/abs/pii/S0925400523004239},
doi = {10.1016/j.snb.2023.133708},
year = {2023},
date = {2023-07-01},
urldate = {2023-07-01},
journal = {Sensors and Actuators B: Chemical},
volume = {386},
pages = {133708},
abstract = {Quartz crystal microbalances (QCMs) coated by polyvinylpyrrolidone (PVP) nanofibers with controlled morphology have been made for ethanol vapor detection. We used electrospinning to deposit PVP nanofibers of different morphologies (spherical-beaded, spindle-beaded, and pure nanofiber) on a QCM surface to study the effect on sensor performance. BET characterization revealed that the spherical-beaded nanofiber had the highest BET-specific surface area than the other morphologies, which improves the QCM sensor sensitivity, limit of quantification (LOQ), limit of detection (LOD), and sensor response. QCM coated with spherical-beaded nanofiber showed improved sensitivity of 2.632 Hz/ppm, lower LOD and LOQ of 0.018 ppm and 0.061 ppm, and better response compared to those coated with spindle-beaded and pure nanofiber. Based on adsorption isotherm models, Freundlich adsorption isotherm was found to be the most suitable for describing ethanol vapor adsorption on the sensor. The high sensitivity of the sensor to ethanol vapor was attributed to hydrogen bonding interactions between the sensor and the ethanol molecules. This study shows that the QCM-based sensor performance can be improved by modifying the morphology of nanofibrous coating layer.},
key = {QCM, Quartz Crystal Microbalance, openQCM Wi2, polyvinylpyrrolidone, nanofibers, ethanol vapor},
keywords = {ethanol vapor, Nanofibers, openQCM Wi2, polyvinylpyrrolidone, QCM, Quartz Crystal Microbalance},
pubstate = {published},
tppubtype = {article}
}
Min, Hyun Jung; Mina, Hansel A; Deering, Amanda J; Rajwa, Bartek; Shin, Sungho; Doh, Iyll-Joon; Robinson, J Paul; Bae, Euiwon
Smartphone-based pathogen detection using concurrent monitoring of resonant frequency and optical fluorescence Inproceedings
In: Sensing for Agriculture and Food Quality and Safety XV, pp. 81–87, SPIE 2023.
Abstract | Links | BibTeX | Tags: Fluorescence, Imaging, openQCM, QCM, Quartz Crystal Microbalance
@inproceedings{min2023smartphone,
title = {Smartphone-based pathogen detection using concurrent monitoring of resonant frequency and optical fluorescence},
author = {Hyun Jung Min and Hansel A Mina and Amanda J Deering and Bartek Rajwa and Sungho Shin and Iyll-Joon Doh and J Paul Robinson and Euiwon Bae},
url = {https://www.spiedigitallibrary.org/conference-proceedings-of-spie/12545/125450A/Smartphone-based-pathogen-detection-using-concurrent-monitoring-of-resonant-frequency/10.1117/12.2665235.short?SSO=1},
doi = {https://doi.org/10.1117/12.2665235},
year = {2023},
date = {2023-06-13},
urldate = {2023-06-13},
booktitle = {Sensing for Agriculture and Food Quality and Safety XV},
volume = {12545},
pages = {81--87},
organization = {SPIE},
abstract = {Recently, the use of a Quartz Crystal Microbalance (QCM) as a biosensor for detecting foodborne pathogens by observing changes in resonant frequency has gained popularity. However, conventional detection methods are time-consuming and require expensive equipment and trained personnel. The current trend is toward detection approaches that are quick, portable, and easy to use. In order to address this need, a dual-modality QCM system combining a smartphone, an in-situ fluorescence imaging subsystem, and a flow injection component has been proposed. This system enables a smartphone to receive real-time frequency data via Bluetooth, while a camera detects the presence of bacteria on the quartz crystal surface using a fluorescence-tagged antibody. The fluorescence imaging subsystem utilizes a camera to capture the bacteria fluorescence signal, while the flow injection subsystem employs a mini peristaltic pump and controller to introduce biochemical solutions, antibodies, and bacteria. All components are contained in a 3D cartridge that is portable. FITC images were captured with 5 MHz quartz crystals when the prototype system was tested. The developed QCM biosensor has t},
keywords = {Fluorescence, Imaging, openQCM, QCM, Quartz Crystal Microbalance},
pubstate = {published},
tppubtype = {inproceedings}
}
Ermek, Erhan; Ayan, Esra; Tokay, Nurettin; DeMirci, Hasan; Kepceoğlu, Abdullah
Electrospun biotin-and streptavidin-coated quartz crystal microbalance surfaces: characterization and mass sensing performance using OpenQCM Journal Article
In: 2023.
Abstract | Links | BibTeX | Tags: Biosensing, Biotin, Electrospinning, openQCM, QCM, Quartz Crystal Microbalance, Raman spectroscopy, Streptavidin, Surface coating
@article{ermek2023electrospun,
title = {Electrospun biotin-and streptavidin-coated quartz crystal microbalance surfaces: characterization and mass sensing performance using OpenQCM},
author = {Erhan Ermek and Esra Ayan and Nurettin Tokay and Hasan DeMirci and Abdullah Kepceoğlu},
url = {https://www.researchsquare.com/article/rs-2995721/v1},
doi = {https://doi.org/10.21203/rs.3.rs-2995721/v1},
year = {2023},
date = {2023-06-06},
urldate = {2023-06-06},
abstract = {In this study, a quartz crystal microbalance (QCM) sensor surface was coated with biotin and/or streptavidin using the electrospinning method. The coated surfaces were analyzed using the Raman spectroscopy method. QCM measurements were carried out using the OpenQCM platform. The results indicate that the electrospinning method can be used to coat QCM surfaces with biotin and/or streptavidin and that the coated surfaces exhibit distinct morphological and spectroscopic properties. The QCM measurements showed that the coated surfaces are highly sensitive to changes in mass, indicating their potential for use in biosensing applications. Overall, this study provides new insights into the use of QCM sensors coated with biotin and/or streptavidin for biological sensing and detection applications.},
keywords = {Biosensing, Biotin, Electrospinning, openQCM, QCM, Quartz Crystal Microbalance, Raman spectroscopy, Streptavidin, Surface coating},
pubstate = {published},
tppubtype = {article}
}
Malhotra, Jaskaran Singh; Kubus, Mariusz; Pedersen, Kasper Steen; Andersen, Simon Ivar; Sundberg, Jonas
Room-temperature monitoring of CH4 and CO2 using a metal-organic framework-based QCM sensor showing inherent analyte discrimination Journal Article
In: 2023.
Abstract | Links | BibTeX | Tags: carbon dioxide, CH4, CO2, Dissipation, metal-organic frameworks, methane, openQCM NEXT, QCM, QCM-D, Quartz Crystal Microbalance, sensors
@article{malhotra2023room,
title = {Room-temperature monitoring of CH4 and CO2 using a metal-organic framework-based QCM sensor showing inherent analyte discrimination},
author = {Jaskaran Singh Malhotra and Mariusz Kubus and Kasper Steen Pedersen and Simon Ivar Andersen and Jonas Sundberg},
url = {https://chemrxiv.org/engage/chemrxiv/article-details/646b938eccabde9f6e2fd280},
doi = {https://doi.org/10.26434/chemrxiv-2023-djhp2},
year = {2023},
date = {2023-05-24},
urldate = {2023-05-24},
abstract = {The detection of methane and carbon dioxide is of growing importance due to their negative impact on global warming. This is true both for environmental monitoring, as well as leak detection in industrial processes. Although solid-state sensors are technologically mature, they have limitations that prohibit their use in certain situations, e.g., explosive atmospheres. Thus, there is a need to develop new types of sensor materials. Herein, we demonstrate a simple, low-cost metal-organic framework-based gas leak detection sensor. The system is based on gravimetric sensing using a quartz crystal microbalance. The quartz crystal is functionalized by layer-by-layer growth of a thin metal-organic framework film. This film shows selective uptake of methane or carbon dioxide under atmospheric conditions. The hardware has low cost, simple operation, and theoretically high sensitivity. Overall, the sensor is characterized by simplicity and high robustness. Furthermore, by exploiting the different adsorption kinetics as measured by multiple harmonics analyses, it is possible to discriminate whether the response is due to methane or carbon dioxide. In summary, we demonstrate data relevant towards new applications of metal-organic frameworks and microporous hybrid materials in sensing applications.},
keywords = {carbon dioxide, CH4, CO2, Dissipation, metal-organic frameworks, methane, openQCM NEXT, QCM, QCM-D, Quartz Crystal Microbalance, sensors},
pubstate = {published},
tppubtype = {article}
}
Lino, Catarina; Barrias, Sara; Chaves, Raquel; Adega, Filomena; Fernandes, José Ramiro; Martins-Lopes, Paula
Development of a QCM-based biosensor for the detection of non-small cell lung cancer biomarkers in liquid biopsies Journal Article
In: Talanta, pp. 124624, 2023.
Abstract | Links | BibTeX | Tags: biosensors, blood plasma, Cancer, DNA, openQCM Q-1, QCM, Quartz Crystal Microbalance
@article{lino2023development,
title = {Development of a QCM-based biosensor for the detection of non-small cell lung cancer biomarkers in liquid biopsies},
author = {Catarina Lino and Sara Barrias and Raquel Chaves and Filomena Adega and José Ramiro Fernandes and Paula Martins-Lopes},
url = {https://www.sciencedirect.com/science/article/pii/S0039914023003752},
doi = {https://doi.org/10.1016/j.talanta.2023.124624},
year = {2023},
date = {2023-05-04},
urldate = {2023-05-04},
journal = {Talanta},
pages = {124624},
publisher = {Elsevier},
abstract = {Lung cancer is the main malignant cancer reported worldwide, with one of the lowest survival rates. Deletions in the Epidermal Growth Factor Receptor (EGFR) gene are often associated with non-small cell lung cancer (NSCLC), a common subtype of lung cancer. The detection of such mutations provides key information for the diagnosis and treatment of the disease; therefore, the early screening of such biomarkers is of vital importance. The need for fast, reliable, and early detection means applied to NSCLC has led to the development of highly sensitive devices that can detect cancer-associated mutations. Such devices, known as biosensors, are a promising alternative to more conventional detection methods and can potentially alter the way cancer is diagnosed and treated. In this study, we report the development of a DNA-based biosensor, namely a quartz crystal microbalance (QCM), applied to the detection of NSCLC, from liquid biopsies samples. The detection, as is the case of most DNA biosensors, is based on the hybridization between the NSCLC-specific probe and the sample DNA (containing specific mutations associated with NSCLC). The surface functionalization was performed with a blocking agent (dithiothreitol) and thiolated-ssDNA strands. The biosensor was able to detect specific DNA sequences in both synthetic and real samples. Aspects such as reutilization and regeneration of the QCM electrode were also studied.},
key = {QCM, Quartz Crystal Microbalance, openQCM Q-1, DNA, cancer, biosensor, blood plasma},
keywords = {biosensors, blood plasma, Cancer, DNA, openQCM Q-1, QCM, Quartz Crystal Microbalance},
pubstate = {published},
tppubtype = {article}
}
Lim, Hui Jean; Saha, Tridib; Tey, Beng Ti; Lal, Sunil Kumar; Ooi, Chien Wei
In: Surfaces and Interfaces, pp. 102904, 2023.
Abstract | Links | BibTeX | Tags: molecularly imprinting, openQCM Q-1, polydopamine, proteins, QCM, Quartz Crystal Microbalance, sensing films
@article{lim2023quartz,
title = {Quartz crystal microbalance-based biosensing of proteins using molecularly imprinted polydopamine sensing films: Interplay between protein characteristics and molecular imprinting effect},
author = {Hui Jean Lim and Tridib Saha and Beng Ti Tey and Sunil Kumar Lal and Chien Wei Ooi},
url = {https://www.sciencedirect.com/science/article/abs/pii/S2468023023002742},
doi = {https://doi.org/10.1016/j.surfin.2023.102904},
year = {2023},
date = {2023-04-29},
urldate = {2023-04-29},
journal = {Surfaces and Interfaces},
pages = {102904},
publisher = {Elsevier},
abstract = {Biomimetic sensing films based on molecularly imprinted polydopamine (MIPDA) offer a simple, biocompatible, and versatile approach to functionalise quartz crystal microbalance (QCM)-based biosensors for the recognition of target proteins. This study aims to investigate the chemical, morphological, and recognition properties of MIPDA sensing films polymerised on the QCM crystal surface and elucidate the impacts of various parameters on the liquid-phase biosensing behaviour. Pepsin, bovine serum albumin, human serum albumin, and lysozyme were used as model proteins to study the effect of molecular imprinting and the influence of protein characteristics on the recognition behaviour of MIPDA-functionalised QCM crystals. Analysis of the protein adsorption patterns revealed that the MIPDA film contained heterogeneous binding sites with a dissociation constant in the µM range, showing that the binding affinity of the synthetic sensing film for the target protein was comparable to that of commonly used bioreceptors. In a case study using a pepsin-imprinted MIPDA film, the specific conformation and surface chemistry of the recognition cavities were discovered to promote the binding of pepsin (imprinting factor = 5.78) while simultaneously reducing the nonspecific binding of incompatible proteins on the QCM crystal surface. Protein recognition on MIPDA-functionalised QCM crystals was found to be governed by a combination of nonspecific interactions (e.g., electrostatic and polar interactions) between the proteins and the MIPDA sensing film. The findings indicate that increasing the density of selective recognition cavities in the MIPDA film and optimising the sample pH are key strategies to improve the selectivity and sensitivity for protein biosensing.},
keywords = {molecularly imprinting, openQCM Q-1, polydopamine, proteins, QCM, Quartz Crystal Microbalance, sensing films},
pubstate = {published},
tppubtype = {article}
}
Maity, Tanmoy; Malik, Pratibha; Bawari, Sumit; Ghosh, Soumya; Mondal, Jagannath; Haldar, Ritesh
Chemically routed interpore molecular diffusion in metal-organic framework thin films Journal Article
In: Nature Communications, vol. 14, no. 1, pp. 2212, 2023.
Abstract | Links | BibTeX | Tags: molecular diffusion, Nanoporous channels, openQCM NEXT, QCM, QCM-D, Quartz Crystal Microbalance
@article{maity2023chemically,
title = {Chemically routed interpore molecular diffusion in metal-organic framework thin films},
author = {Tanmoy Maity and Pratibha Malik and Sumit Bawari and Soumya Ghosh and Jagannath Mondal and Ritesh Haldar},
url = {https://pubmed.ncbi.nlm.nih.gov/37072404/},
doi = {https://doi.org/10.1038/s41467-023-37739-8},
year = {2023},
date = {2023-04-18},
urldate = {2023-04-18},
journal = {Nature Communications},
volume = {14},
number = {1},
pages = {2212},
publisher = {Nature Publishing Group UK London},
abstract = {Transport diffusivity of molecules in a porous solid is constricted by the rate at which molecules move from one pore to the other, along the concentration gradient, i.e. by following Fickian diffusion. In heterogeneous porous materials, i.e. in the presence of pores of different sizes and chemical environments, diffusion rate and directionality remain tricky to estimate and adjust. In such a porous system, we have realized that molecular diffusion direction can be orthogonal to the concentration gradient. To experimentally determine this complex diffusion rate dependency and get insight of the microscopic diffusion pathway, we have designed a model nanoporous structure, metal-organic framework (MOF). In this model two chemically and geometrically distinct pore windows are spatially oriented by an epitaxial, layer-by-layer growth method. The specific design of the nanoporous channels and quantitative mass uptake rate measurements have indicated that the mass uptake is governed by the interpore diffusion along the direction orthogonal to the concentration gradient. This revelation allows chemically carving the nanopores, and accelerating the interpore diffusion and kinetic diffusion selectivity.},
keywords = {molecular diffusion, Nanoporous channels, openQCM NEXT, QCM, QCM-D, Quartz Crystal Microbalance},
pubstate = {published},
tppubtype = {article}
}
Rohman, Yadi Mulyadi; Sukowati, Riris; Priyanto, Aan; Hapidin, Dian Ahmad; Edikresnha, Dhewa; Khairurrijal, Khairurrijal
Quartz Crystal Microbalance Coated with Polyacrylonitrile/Nickel Nanofibers for High-Performance Methanol Gas Detection Journal Article
In: ACS Omega, 2023.
Abstract | Links | BibTeX | Tags: Alcohols, Nanofibers, nanoparticles, Nickel, openQCM Wi2, QCM, Quartz Crystal Microbalance, sensors
@article{rohman2023quartz,
title = {Quartz Crystal Microbalance Coated with Polyacrylonitrile/Nickel Nanofibers for High-Performance Methanol Gas Detection},
author = {Yadi Mulyadi Rohman and Riris Sukowati and Aan Priyanto and Dian Ahmad Hapidin and Dhewa Edikresnha and Khairurrijal Khairurrijal},
url = {https://pubs.acs.org/doi/full/10.1021/acsomega.3c00760},
doi = {https://doi.org/10.1021/acsomega.3c00760},
year = {2023},
date = {2023-03-29},
urldate = {2023-01-01},
journal = {ACS Omega},
publisher = {ACS Publications},
abstract = {This study describes a sensor based on quartz crystal microbalance (QCM) coated by polyacrylonitrile (PAN) nanofibers containing nickel nanoparticles for methanol gas detection. The PAN/nickel nanofibers composites were made via electrospinning and electrospray methods. The QCM sensors coated with the PAN/nickel nanofiber composite were evaluated for their sensitivities, selectivities, and stabilities. The morphologies and elemental compositions of the sensors were examined using a scanning electron microscope-energy dispersive X-ray. A Fourier Transform Infrared spectrometer was used to investigate the elemental bonds within the nanofiber composites. The QCM sensors coated with PAN/nickel nanofibers offered a high specific surface area to enhance the QCM sensing performance. They exhibited excellent sensing characteristics, including a high sensitivity of 389.8 ± 3.8 Hz/SCCM, response and recovery times of 288 and 251 s, respectively, high selectivity for methanol compared to other gases, a limit of detection (LOD) of about 1.347 SCCM, and good long-term stability. The mechanism of methanol gas adsorption by the PAN/nickel nanofibers can be attributed to intermolecular interactions, such as the Lewis acid–base reaction by PAN nanofibers and hydrogen bonding by nickel nanoparticles. The results suggest that QCM-coated PAN/nickel nanofiber composites show great potential for the design of highly sensitive and selective methanol gas sensors.},
key = {Alcohols,Nanofibers,Nanoparticles,Nickel,Sensors},
keywords = {Alcohols, Nanofibers, nanoparticles, Nickel, openQCM Wi2, QCM, Quartz Crystal Microbalance, sensors},
pubstate = {published},
tppubtype = {article}
}
Qi, Shaojun; Kiratzis, Ioannis; Adoni, Pavan; Tuekprakhon, Aekkachai; Hill, Harriet James; Stamataki, Zania; Nabi, Aneesa; Waugh, David; Rodriguez, Javier Rodriguez; Clarke, Stuart Matthew; others,
Porous Cellulose Thin Films as Sustainable and Effective Antimicrobial Surface Coatings Journal Article
In: ACS Applied Materials & Interfaces, 2023.
Abstract | Links | BibTeX | Tags: antimicrobial, cellulose, evaporation, film, openQCM NEXT, QCM, QCM-D, Quartz Crystal Microbalance, robustness, SARS-CoV-2
@article{qi2023porous,
title = {Porous Cellulose Thin Films as Sustainable and Effective Antimicrobial Surface Coatings},
author = {Shaojun Qi and Ioannis Kiratzis and Pavan Adoni and Aekkachai Tuekprakhon and Harriet James Hill and Zania Stamataki and Aneesa Nabi and David Waugh and Javier Rodriguez Rodriguez and Stuart Matthew Clarke and others},
url = {https://pubs.acs.org/doi/full/10.1021/acsami.2c23251},
doi = {https://doi.org/10.1021/acsami.2c23251},
year = {2023},
date = {2023-03-29},
urldate = {2023-01-01},
journal = {ACS Applied Materials & Interfaces},
publisher = {ACS Publications},
abstract = {In the present work, we developed an effective antimicrobial surface film based on sustainable microfibrillated cellulose. The resulting porous cellulose thin film is barely noticeable to human eyes due to its submicrometer thickness, of which the surface coverage, porosity, and microstructure can be modulated by the formulations and the coating process. Using goniometers and a quartz crystal microbalance, we observed a threefold reduction in water contact angles and accelerated water evaporation kinetics on the cellulose film (more than 50% faster than that on a flat glass surface). The porous cellulose film exhibits a rapid inactivation effect against SARS-CoV-2 in 5 min, following deposition of virus-loaded droplets, and an exceptional ability to reduce contact transfer of liquid, e.g., respiratory droplets, to surfaces such as an artificial skin by 90% less than that from a planar glass substrate. It also shows excellent antimicrobial performance in inhibiting the growth of both Gram-negative and Gram-positive bacteria (Escherichia coli and Staphylococcus epidermidis) due to the intrinsic porosity and hydrophilicity. Additionally, the cellulose film shows nearly 100% resistance to scraping in dry conditions due to its strong affinity to the supporting substrate but with good removability once wetted with water, suggesting its practical suitability for daily use. Importantly, the coating can be formed on solid substrates readily by spraying, which requires solely a simple formulation of a plant-based cellulose material with no chemical additives, rendering it a scalable, affordable, and green solution as antimicrobial surface coating. Implementing such cellulose films could thus play a significant role in controlling future pan- and epidemics, particularly during the initial phase when suitable medical intervention needs to be developed and deployed.},
key = {cellulose, film, antimicrobial, evaporation, SARS-CoV-2, robustness},
keywords = {antimicrobial, cellulose, evaporation, film, openQCM NEXT, QCM, QCM-D, Quartz Crystal Microbalance, robustness, SARS-CoV-2},
pubstate = {published},
tppubtype = {article}
}
Bulut, Aliye; Temur, Betul Z; Kirimli, Ceyhun E; Gok, Ozgul; Balcioglu, Bertan K; Ozturk, Hasan U; Uyar, Neval Y; Kanlidere, Zeynep; Kocagoz, Tanil; Can, Ozge
A Novel Peptide-Based Detection of SARS-CoV-2 Antibodies Journal Article
In: Biomimetics, vol. 8, no. 1, pp. 89, 2023.
Abstract | Links | BibTeX | Tags: antibody detection, biosensors, peptide mimetics, QCM, Quartz Crystal Microbalance, SARS-CoV-2
@article{bulut2023novel,
title = {A Novel Peptide-Based Detection of SARS-CoV-2 Antibodies},
author = {Aliye Bulut and Betul Z Temur and Ceyhun E Kirimli and Ozgul Gok and Bertan K Balcioglu and Hasan U Ozturk and Neval Y Uyar and Zeynep Kanlidere and Tanil Kocagoz and Ozge Can},
url = {https://www.mdpi.com/2313-7673/8/1/89},
doi = {https://doi.org/10.3390/biomimetics8010089},
year = {2023},
date = {2023-02-22},
urldate = {2023-02-22},
journal = {Biomimetics},
volume = {8},
number = {1},
pages = {89},
publisher = {MDPI},
abstract = {The need for rapidly developed diagnostic tests has gained significant attention after the recent pandemic. Production of neutralizing antibodies for vaccine development or antibodies to be used in diagnostic tests usually require the usage of recombinant proteins representing the infectious agent. However, peptides that can mimic these recombinant proteins may be rapidly utilized, especially in emergencies such as the recent outbreak. Here, we report two peptides that mimic the receptor binding domain of the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and investigate their binding behavior against the corresponding human immunoglobulin G and immunoglobulin M (IgG and IgM) antibodies in a clinical sample using a quartz crystal microbalance (QCM) sensor. These peptides were immobilized on a QCM sensor surface, and their binding behavior was studied against a clinical serum sample that was previously determined to be IgG and IgM-positive. It was determined that designed peptides bind to SARS-CoV-2 antibodies in a clinical sample. These peptides might be useful for the detection of SARS-CoV-2 antibodies using different methods such as enzyme-linked immunosorbent assay (ELISA) or lateral flow assays. A similar platform might prove to be useful for the detection and development of antibodies in other infections.},
key = {peptide mimetics, SARS-CoV-2, biosensor, quartz crystal microbalance, antibody detection},
keywords = {antibody detection, biosensors, peptide mimetics, QCM, Quartz Crystal Microbalance, SARS-CoV-2},
pubstate = {published},
tppubtype = {article}
}
Hajizadehmotlagh, Mandana; Fahimi, Dorsa; Singhal, Anuj; Paprotny, Igor
Wearable Resonator-Based Respirable Dust Monitor for Underground Coal Mines Journal Article
In: IEEE Sensors Journal, vol. 23, no. 7, pp. 6680–6687, 2023.
Links | BibTeX | Tags: Airborne, Diesel Exhaust, Dust, gravimetry, openQCM, QCM, Quartz Crystal Microbalance, Respirable Coal Dust
@article{hajizadehmotlagh2023wearable,
title = {Wearable Resonator-Based Respirable Dust Monitor for Underground Coal Mines},
author = {Mandana Hajizadehmotlagh and Dorsa Fahimi and Anuj Singhal and Igor Paprotny},
url = {https://ieeexplore.ieee.org/abstract/document/10047920},
doi = {https://doi.org/10.1109/JSEN.2023.3241601},
year = {2023},
date = {2023-02-16},
urldate = {2023-02-16},
journal = {IEEE Sensors Journal},
volume = {23},
number = {7},
pages = {6680--6687},
publisher = {IEEE},
keywords = {Airborne, Diesel Exhaust, Dust, gravimetry, openQCM, QCM, Quartz Crystal Microbalance, Respirable Coal Dust},
pubstate = {published},
tppubtype = {article}
}
Massera, Ettore; Barretta, Luigi; Miglietta, Maria Lucia; Alfano, Brigida; Polichetti, Tiziana
Quartz Crystal Microbalance Study in Controlled Environment for Particulate Matter Sensing Incollection
In: Sensors and Microsystems: Proceedings of AISEM 2022, pp. 129–134, Springer, 2023.
Abstract | Links | BibTeX | Tags: air quality, environment, graphene, pollution, QCM, Quartz Crystal Microbalance
@incollection{massera2023quartz,
title = {Quartz Crystal Microbalance Study in Controlled Environment for Particulate Matter Sensing},
author = {Ettore Massera and Luigi Barretta and Maria Lucia Miglietta and Brigida Alfano and Tiziana Polichetti},
url = {https://link.springer.com/chapter/10.1007/978-3-031-25706-3_21},
doi = {https://doi.org/10.1007/978-3-031-25706-3_21},
year = {2023},
date = {2023-02-02},
urldate = {2023-01-01},
booktitle = {Sensors and Microsystems: Proceedings of AISEM 2022},
pages = {129--134},
publisher = {Springer},
abstract = {Today, air quality sensors miniaturization is a trending topic for industry research. Market demand for wearable devices with “internet of things” capabilities has exponential growth. Particulate matter sensors in consumer electronics are all based on the optical particles counter mechanism and are always too bulky. As an interesting alternative we propose a study on a commercial quartz crystal microbalance showing the correlation between its electronic features and the measurement of the particulate matter present in the air with a reference instrument. We also present preliminary measurements for a quartz crystal microbalance which surface is covered by a layer of graphene nanoplatelets making a comparison with the pristine one.},
key = {QCM, Quartz Crystal Microbalance, Sensor, pollution, air quality, graphene},
keywords = {air quality, environment, graphene, pollution, QCM, Quartz Crystal Microbalance},
pubstate = {published},
tppubtype = {incollection}
}
György, Dr. Csilla; Kirkman, Dr. Paul M.; Neal, Dr. Thomas J.; Chan, Dr. Derek H. H.; Williams, Megan; Smith, Dr. Timothy; Growney, Dr. David J.; Armes, Prof. Steven P.
Enhanced Adsorption of Epoxy-Functional Nanoparticles onto Stainless Steel Significantly Reduces Friction in Tribological Studies Journal Article
In: Angewandte Chemie International Edition, 2023.
Abstract | Links | BibTeX | Tags: epoxy-functional noparticles, nanoparticles, polymerization, polymerization-induced, QCM-D, Quartz Crystal Microbalance, RAFT, self-assembly, stainless steel
@article{armesenhanced,
title = {Enhanced Adsorption of Epoxy-Functional Nanoparticles onto Stainless Steel Significantly Reduces Friction in Tribological Studies},
author = {Dr. Csilla György and Dr. Paul M. Kirkman and Dr. Thomas J. Neal and Dr. Derek H. H. Chan and Megan Williams and Dr. Timothy Smith and Dr. David J. Growney and Prof. Steven P. Armes},
url = {https://onlinelibrary.wiley.com/doi/10.1002/anie.202218397},
doi = {https://doi.org/10.1002/anie.202218397},
year = {2023},
date = {2023-01-18},
urldate = {2023-01-18},
journal = {Angewandte Chemie International Edition},
publisher = {Wiley Online Library},
abstract = {Epoxy-functional sterically-stabilized diblock copolymer nanoparticles (~27 nm) are prepared via RAFT dispersion polymerization in mineral oil. Nanoparticle adsorption onto stainless steel is examined using a quartz crystal microbalance. Incorporating epoxy groups within the steric stabilizer chains results in a near two-fold increase in the adsorbed amount, Γ, at 20 °C (7.6 mg m-2) compared to epoxy-core functional nanoparticles (3.7 mg m-2) or non-functional nanoparticles (3.8 mg m-2). A larger difference in Γ is observed at 40 °C; this suggests chemical adsorption of the nanoparticles rather than merely physical adsorption. A remarkable near five-fold increase in Γ is observed for larger (~50 nm) epoxy-functional nanoparticles compared to non-functional nanoparticles (31.3 vs. 6.4 mg m-2, respectively). Tribological studies conducted at 60-120 °C confirm that the adsorption of epoxy-functional nanoparticles leads to a significant reduction in the friction coefficient.},
key = {QCM-D, nanoparticles},
keywords = {epoxy-functional noparticles, nanoparticles, polymerization, polymerization-induced, QCM-D, Quartz Crystal Microbalance, RAFT, self-assembly, stainless steel},
pubstate = {published},
tppubtype = {article}
}
Aflaha, Rizky; Afiyanti, Henny; Azizah, Zhafirah Nur; Khoirudin, Hanif; Rianjanu, Aditya; Kusumaatmaja, Ahmad; Roto, Roto; Triyana, Kuwat
Improving ammonia sensing performance of quartz crystal microbalance (QCM) coated with nanofibers and polyaniline (PANi) overlay Journal Article
In: Biosensors and Bioelectronics: X, pp. 100300, 2022.
Abstract | Links | BibTeX | Tags: Ammonia, Nanofiber, Polyaniline, Polyvinyl acetate, Quartz Crystal Microbalance
@article{aflaha2022improving,
title = {Improving ammonia sensing performance of quartz crystal microbalance (QCM) coated with nanofibers and polyaniline (PANi) overlay},
author = {Rizky Aflaha and Henny Afiyanti and Zhafirah Nur Azizah and Hanif Khoirudin and Aditya Rianjanu and Ahmad Kusumaatmaja and Roto Roto and Kuwat Triyana},
url = {https://www.sciencedirect.com/science/article/pii/S2590137022001935},
doi = {https://doi.org/10.1016/j.biosx.2022.100300},
year = {2022},
date = {2022-12-23},
urldate = {2022-01-01},
journal = {Biosensors and Bioelectronics: X},
pages = {100300},
publisher = {Elsevier},
abstract = {Ammonia gas sensors with high sensitivity, good selectivity, and superior stability continue to be developed to monitor ammonia levels in the air. In this study, we developed a sensor based on a quartz crystal microbalance coated with polyvinyl acetate (PVAc) nanofiber overlaid with a polyaniline (PANi) nanocomposite to increase the sensitivity and selectivity of the sensor. The morphology and chemical composition of the fabricated nanofibers were examined by scanning electron microscopy and Fourier transform infrared spectroscopy. PANi nanocomposites were shown to stick to nanofiber, and nanofiber became many active groups after PANi overlay. The QCM sensor coated with the PVAc nanofiber overlaid with 0.05% PANi (PVAc/PANi5) exhibited the highest sensitivity of 0.297 Hz/ppm. This value was increased 5.2 times compared to the sensor without the PANi overlay (0.055 Hz/ppm). The PVAc/PANi5 sensor exhibited good reproducibility, repeatability, and reversibility. Moreover, a rapid response (36 s) and recovery (26 s) time were observed. The sensor also showed good selectivity towards other analytes and was proven to have good long-term stability during two months of testing. This finding may potentially be an alternative method for increasing the ammonia-sensing performance of a sensor through overlaying.},
key = {Polyvinyl acetate, Polyaniline, Ammonia, Quartz crystal microbalance, Nanofiber},
keywords = {Ammonia, Nanofiber, Polyaniline, Polyvinyl acetate, Quartz Crystal Microbalance},
pubstate = {published},
tppubtype = {article}
}
Xu, Jiexiong
Heavy Metal Detection Methods in Water using Quartz Crystal Microbalance PhD Thesis
Purdue University Graduate School, 2022.
Abstract | Links | BibTeX | Tags: biosensors, environment, ligand binding interactions, Quartz Crystal Microbalance, sensors
@phdthesis{xu2022heavy,
title = {Heavy Metal Detection Methods in Water using Quartz Crystal Microbalance},
author = {Jiexiong Xu},
url = {https://hammer.purdue.edu/articles/thesis/Heavy_Metal_Detection_Methods_in_Water_using_Quartz_Crystal_Microbalance/19684002},
doi = {https://doi.org/10.25394/PGS.19684002.v1},
year = {2022},
date = {2022-05-02},
urldate = {2022-01-01},
school = {Purdue University Graduate School},
abstract = {According to the World Health Organization, long-term exposures to heavy metal toxicants such as arsenic (As) and lead (Pb), even at the parts per billion (ppb, μg/L) level, can cause severe health problems such as cancer, skin lesions, and cardiovascular diseases. Therefore, an accurate and rapid heavy metal toxicant monitoring technique is needed. This research investigated the proof-of-the concept of a portable sensor for detecting As and Pb in water. The sensor system utilized a Quartz Crystal Microbalance - QCM (openQCM w-i2) system interfaced with a computer as the sensing platform. It was further integrated with a peristaltic pump and required tubing to create the integrated sensing system. It used a 10 MHz AT-cut quartz crystal gold electrode as the sensing substrate. For the determination of As in water, dithiothreitol (DTT) was used as the ligand to be deposited on the gold electrode using the Self-assembly-monolayer method (SAM). For the determination of Pb, a combination of ligands (Chitosan, Glutaraldehyde, and lead ionophore II - CGL) was used and deposited on the gold electrode using the spin-coating method. The system was tested for As in water with specific concentrations (0, 50, 100, and 200 ppb) under laboratory conditions. Similarly, the system was tested for Pb in water with different concentrations (0, 10, 25, 50, and 100 ppb) under laboratory conditions. The resulted change of frequency (with respect to time, in seconds) of the QCM system to different concentrations of the individual analyte was recorded. Subsequently, the recorded data were analyzed to determine the correlation model and coefficient of determination, R2. The maximum R2 values for detecting As and Pb were 0.963 and 0.991, respectively. Thus, this proof-of-the-concept study using the developed QCM-based sensing system for detecting As and Pb in water was successful.},
key = {Biosensor, ligand binding interactions, sensors, environment},
keywords = {biosensors, environment, ligand binding interactions, Quartz Crystal Microbalance, sensors},
pubstate = {published},
tppubtype = {phdthesis}
}
Matsumoto, Atsushi; Yoshizawa, Ryota; Funari, Riccardo; Urakawa, Osamu; Inoue, Tadashi; Shen, Amy Q
Rheology of the Electric Double Layer In Ionic Liquid Solutions: Effects of Ion Concentration and Anion Structures Journal Article
In: Available at SSRN 4096144, 2022.
Abstract | Links | BibTeX | Tags: Electric Double Layer, Electrostatic Screening, Ionic Liquid, openQCM Q-1, Quartz Crystal Microbalance, Rheology, Viscoelastic Properties
@article{matsumoto4096144rheology,
title = {Rheology of the Electric Double Layer In Ionic Liquid Solutions: Effects of Ion Concentration and Anion Structures},
author = {Atsushi Matsumoto and Ryota Yoshizawa and Riccardo Funari and Osamu Urakawa and Tadashi Inoue and Amy Q Shen},
url = {https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4096144},
doi = {https://dx.doi.org/10.2139/ssrn.4096144},
year = {2022},
date = {2022-04-28},
urldate = {2022-04-28},
journal = {Available at SSRN 4096144},
abstract = {Ionic liquids (IL) are molten salts with melting temperatures below 100°C. Combined with other unique properties such as high thermal and electrochemical stability, non-volatility and high ionic conductivity, they have been used as electrolytes in batteries and lubricants, where the viscoelasticity of the electric double layer (EDL) plays an important role. Due to the small length scale of EDL thickness, it has been challenging to characterize their viscoelastic properties at nanoscale. Herein, by using a quartz crystal microbalance (QCM), we measure the changes in the resonant frequency and energy dissipation of a gold-coated quartz crystal on which IL solutions are deposited. Since the gold surface of the quartz crystal is negatively charged at an open circuit potential, we can estimate the loss modulus of the EDL near the charged surface through a wave propagation model. Using this approach, we investigate the viscoelastic properties of the EDL formed on the quartz crystal from three ionic liquids with different anions: 1-butyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide (Bmim-TFSI); 1-butyl-3-methylimidazolium trifluoromethanesulfonate (Bmim-TfO); 1-butyl-3-methylimidazolium tetrafluoroborate (Bmim-BF4). We find that the loss modulus of the EDL increases rapidly with increasing ionic liquid concentrations in the low concentration regime, but reaches about 3 orders of magnitude larger than the loss modulus of the bulk solution in the higher concentration regime. This behavior is independent of the type of anions. Our results can provide useful information on the rheological properties of the EDL in IL solutions, optimizing IL-based material design with improved system performances.},
keywords = {Electric Double Layer, Electrostatic Screening, Ionic Liquid, openQCM Q-1, Quartz Crystal Microbalance, Rheology, Viscoelastic Properties},
pubstate = {published},
tppubtype = {article}
}
Saffari, Zahra; Sepahi, Mina; Ahangari-Cohan, Reza; Khoobi, Mehdi; Hamidi-Fard, Mojtaba; Ghavidel, Amir; Aghasadeghi, Mohammad Reza; Norouzian, Dariush
A quartz crystal microbalance biosensor based on polyethylenimine-modified gold electrode to detect hepatitis B biomarker Journal Article
In: Analytical Biochemistry, pp. 114981, 2022.
Abstract | Links | BibTeX | Tags: biosensors, Hepatitis B Biomarker, Polyethylenimine, Quartz Crystal Microbalance
@article{saffari2022quartz,
title = {A quartz crystal microbalance biosensor based on polyethylenimine-modified gold electrode to detect hepatitis B biomarker},
author = {Zahra Saffari and Mina Sepahi and Reza Ahangari-Cohan and Mehdi Khoobi and Mojtaba Hamidi-Fard and Amir Ghavidel and Mohammad Reza Aghasadeghi and Dariush Norouzian},
url = {https://www.sciencedirect.com/science/article/abs/pii/S0003269722004419},
doi = {https://doi.org/10.1016/j.ab.2022.114981},
year = {2022},
date = {2022-01-01},
urldate = {2022-01-01},
journal = {Analytical Biochemistry},
pages = {114981},
publisher = {Elsevier},
abstract = {Biomarkers-based QCM-biosensors are suitable tools for the label-free detection of infectious diseases. In the current study, a QCM-biosensor was developed for the detection of HBsAg. Briefly, anti-HBsAg antibodies were covalently bound to the primary amines after PEI and thiolated-PEI surface modifications of gold-electrode. After RSM optimization, the statistical analysis revealed no significant difference between the immobilization yields of modified layers. Therefore, the PEI-modified QCM-biosensor was selected for further analysis. The PEI-surface was evaluated by FESEM, AFM, ATR-FTIR, and CA measurement. The surface hydrophilicity and its roughness were increased after PEI-coating. Also, FTIR confirmed the PEI-layering on the gold-surface. RSM optimization increased the antibody immobilization yield up to 80%. The QCM-biosensor showed noteworthy results with a wide dynamic range of 1–1 × 103 ng/mL, LOD of 3.14 ng/mL, LOQ of 9.52 ng/mL, and detection capability in human-sera, which were comparable with the ELISA. The mean accuracy of the QCM-biosensor was obtained at 91% when measured by the spike recovery test using human-sera. The biosensor was completely regenerated using 50 mM NaOH and 1% SDS. The benefits provided by the developed biosensor such as broad dynamic range, sensitivity, selectivity, stability, regenerate ability, and low cost suggest its potential application for the non-invasive and timely monitoring of HBV-biomarker.},
key = {Hepatitis B Biomarker, Biosensor, Quartz crystal microbalance, Polyethylenimine, Gold electrode},
keywords = {biosensors, Hepatitis B Biomarker, Polyethylenimine, Quartz Crystal Microbalance},
pubstate = {published},
tppubtype = {article}
}
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