# Real-time kinetic analysis and detection of glycated hemoglobin A1c using a quartz crystal microbalance-based aptasensor

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- Authors: Yossawadee Sriondee, Pasara Vijitvarasan, Arunothai Rattanachata, Hideki Nakajima, Sukunya Oaew, Sarawut Cheunkar
- Journal: Analytical Methods
- Year: 2024
- Volume: 16
- Pages: 599-607
- DOI: 10.1039/D3AY01842C
- Instrument used: openQCM Sensors, openQCM Wi2

## Abstract

Glycated hemoglobin (HbA1c) is an important biomarker for the long-term diagnosis and monitoring of diabetes mellitus. Here, an aptamer specific to HbA1c was covalently functionalized onto a QCM substrate via mixed self-assembled monolayers (SAMs). A portable QCM equipped with a liquid-flow module was used to investigate the biospecificity, sensitivity and interaction dynamics of the aptamer-functionalized surfaces. The aptasensor showed highly specific recognition of HbA1c with an equilibrium dissociation constant of 57.99 nM, a linear detection range from 13 to 108 nM, and a limit of detection of 26.29 nM.

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