# Quartz Crystal Microbalance Assay of Clinical Calcinosis Samples and Their Synthetic Models Differentiates the Efficacy of Chelation-Based Treatments

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- Authors: Fan Fei, Andrzej Gallas, Yun-Chuan Chang, Yikun Rao, Alan Christy Hunter, Richard E. P. Winpenny, Ariane L. Herrick, Nicholas P. Lockyer, Christopher F. Blanford
- Journal: ACS Applied Materials & Interfaces
- Year: 2017
- Volume: 9
- Pages: 27544–27552
- DOI: 10.1021/acsami.7b08423
- Instrument used: openQCM

## Abstract

This paper sets out in vitro protocols for studying the relative effectiveness of chelators used in the dissolution-based treatment of hard calcinosis. Pulverized hard calcinosis samples from human donors or synthetic hydroxyapatite nanoparticles were deposited by electrophoretic deposition on the surface of a quartz crystal microbalance sensor. Over 150 deposits of

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