# A biofilm-derived peptide as an underwater adhesive

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- Authors: Xin Huang, Ewelina D. Liszczyk, Ramesh Prasad, Megan E. Mitchell, Zhijie Wang, Yuchu Liu, Sarvagya Saluja, Mingyu Wang, Rebekah A. Jackson, Peter Dahl, Roberto C. Andresen Eguiluz, Nikhil Malvankar, Elsa C. Y. Yan, Rich Olson, Huan‐Xiang Zhou, Jing Yan
- Journal: bioRxiv (Cold Spring Harbor Laboratory)
- Year: 2026
- DOI: 10.64898/2026.08.05.742774
- Instrument used: openQCM NEXT

## Abstract

Abstract Wet adhesives that perform under water have broad applications in industrial and biomedical settings. To date, molecular designs for underwater adhesives have largely been inspired by marine animals including mussels and barnacles. Here, we propose bacterial biofilms as an alternative source of inspiration for underwater adhesives. Specifically, we demonstrate the application potential of a peptide derived from biofilms formed by the notorious pathogen Vibrio cholerae . We characterize the ability of this biofilm-derived peptide to adsorb onto various surfaces and to glue wet surfaces, by using a combination of confocal microscopy, molecular dynamics simulations, atomic force microscopy, lap shear tests, and spectroscopic tools. We further show that the peptide can co-aggregate with microspheres acting as an effective flocculant. Finally, we succeeded in purifying this peptide from E. coli in a functional form, setting the stage for large-scale production. Our results open new design possibilities for underwater adhesives inspired by natural biofilms. Teaser A peptide derived from biofilms adheres to diverse surfaces and shows promising potential as a wet adhesive and flocculant.

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